Moeller Sebastian, Kalkwarf Neele, Lücke Caroline, Ortiz Diana, Jahn Sonja, Först Christiane, Braun Niclas, Philipsen Alexandra, Müller Helge H O
Medical Campus University of Oldenburg, School of Medicine and Health Sciences, Psychiatry and Psychotherapy-University Hospital Geriatric Psychiatry ECT Unit, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany.
Medicine (Baltimore). 2017 Dec;96(48):e8813. doi: 10.1097/MD.0000000000008813.
Up to one third of all schizophrenic patients are classified as having treatment-resistant schizophrenia (TRS). This subgroup faces remarkable medical and psychosocial damages, and pharmacotherapy is often limited due to nonresponse and/or side effects. Maintenance electroconvulsive therapy (M-ECT) might be effective in TRS.
We present a case of a 26-year-old male patient with a TRS.
He received a treatment series of ECT sessions and a course of 24 M-ECTs.
The entire treatment was tolerated without significant side effects.
Moreover, the Psychotic Symptom Rating Scale (PSYRATS) scores for both positive and negative symptoms decreased and remained stable over the course of M-ECT.
Because of the remarkable improvement in the negative and positive symptom clusters, we propose systematic examinations in the field of M-ECT in TRS patients. These studies should integrate long-term outcome and tolerance measurements, gaining insight into the optimal duration of treatment for this indication.
高达三分之一的精神分裂症患者被归类为患有难治性精神分裂症（TRS）。这一亚组患者面临着显著的医学和心理社会损害，并且由于无反应和/或副作用，药物治疗往往受到限制。维持性电休克治疗（M-ECT）可能对TRS有效。
我们报告一例26岁的难治性精神分裂症男性患者。
他接受了一系列电休克治疗以及24次M-ECT疗程。
整个治疗过程耐受性良好，无明显副作用。
此外，在M-ECT治疗过程中，阳性和阴性症状的精神病症状评定量表（PSYRATS）评分均下降并保持稳定。
由于阴性和阳性症状群有显著改善，我们建议对TRS患者进行M-ECT领域的系统检查。这些研究应整合长期结果和耐受性测量，深入了解该适应症的最佳治疗持续时间。
