Tekdemir Emrah, Tatlipinar Arzu, Özbeyli Dilek, Tekdemir Özge, Kınal Emrah
a ENT Clinic , Fatih Sultan Mehmet Training and Research Hospital , Kozyatagi , Istanbul , Turkey.
b Experimental Animal Laboratory , Marmara University School of Medicine , Uskudar , Istanbul , Turkey.
Acta Otolaryngol. 2018 Jun;138(6):537-541. doi: 10.1080/00016489.2017.1420914. Epub 2018 Jan 8.
To investigate the effects of lipoic acid and methylprednisolone on nerve healing in rats with traumatic facial paralysis.
The rats were randomly divided into four groups, with six rats in the control group and eight each in the remaining three groups. The buccal branch of the facial nerve in all groups except the control group was traumatized by a vascular clamp for 40 minutes. Group 1 was given lipoic acid (LA), Group 2 was given methylprednisolone (MP), and Group 3 was given lipoic acid and methylprednisolone (LA + MP) for one week. Nerve stimulus thresholds were measured before trauma, after trauma and at the end of the one week treatment period.
When the groups were compared with each other, post-treatment threshold levels of LA + MP were significantly lower than LA. Although post-treatment threshold levels of LA and MP were still higher than the control group, there was no significant difference between LA + MP and control values (p > .05).
Lipoic acid has a positive effect on nerve healing and can enhance the effect of methylprednisolone treatment. It is a good alternative in cases where methylprednisolone cannot be used.
探讨硫辛酸和甲泼尼龙对创伤性面神经麻痹大鼠神经愈合的影响。
将大鼠随机分为四组，对照组6只，其余三组每组8只。除对照组外，所有组的面神经颊支均用血管夹夹闭40分钟造成损伤。第1组给予硫辛酸（LA），第2组给予甲泼尼龙（MP），第3组给予硫辛酸和甲泼尼龙（LA + MP），持续一周。在创伤前、创伤后及一周治疗期结束时测量神经刺激阈值。
各组相互比较时，LA + MP治疗后的阈值水平显著低于LA组。虽然LA和MP治疗后的阈值水平仍高于对照组，但LA + MP与对照组值之间无显著差异（p > .05）。
硫辛酸对神经愈合有积极作用，可增强甲泼尼龙的治疗效果。在不能使用甲泼尼龙的情况下，它是一个很好的替代选择。
