Salomone Raquel, Jácomo Alfredo Luiz, Nascimento Silvia Bona do, Lezirovitz Karina, Hojaij Flávio Carneiro, Costa Heloisa Juliana Zabeu Rossi, Bento Ricardo Ferreira
Department of Otorhinolaryngology, University of São Paulo Medical School, São Paulo, Brazil.
Department of Surgery, Discipline of Human Structural Topography, University of São Paulo Medical School, São Paulo, Brazil.
Head Neck. 2018 Jul;40(7):1489-1497. doi: 10.1002/hed.25122. Epub 2018 Mar 9.
Recent studies in invertebrates have taught us that early cell membrane regeneration is determinant for axonal recovery and survival after trauma. Many authors obtained extraordinary results in neural regeneration using polyethylene glycol fusion protocols, which also involved microsutures and antioxidants.
Sixty rats were evaluated with functional and histological protocol after facial nerve neurotmesis. Groups A and B had their stumps coapted with microsuture after 24 hours of neurotmesis and groups C and D after 72 hours. In addition to the microstructure, groups B and D used the polyethylene glycol-fusion protocol for the modulation of the Ca .
At the sixth week, the latency of group D and duration of group B was lower than groups A and C (P = .011). The axonal diameter of the groups that used polyethylene glycol-fusion was higher than those who did not use polyethylene glycol-fusion (P ≤ .001).
Although not providing a functional improvement, polyethylene glycol-fusion slowed down demyelination.
近期对无脊椎动物的研究让我们了解到，早期细胞膜再生对于创伤后轴突的恢复和存活至关重要。许多作者使用聚乙二醇融合方案在神经再生方面取得了非凡成果，该方案还涉及显微缝合和抗氧化剂。
60只大鼠在面神经切断术后接受功能和组织学评估。A组和B组在神经切断24小时后用显微缝合对接残端，C组和D组在72小时后对接。除微观结构外，B组和D组使用聚乙二醇融合方案来调节钙离子。
在第六周时，D组的潜伏期和B组的持续时间低于A组和C组（P = 0.011）。使用聚乙二醇融合的组的轴突直径高于未使用聚乙二醇融合的组（P≤0.001）。
虽然未提供功能改善，但聚乙二醇融合减缓了脱髓鞘。
