Bohnensack R
Biomed Biochim Acta. 1985;44(6):853-62.
A mathematical model of mitochondrial energy transduction is presented. The model contains rate equations for the main steps of oxidative phosphorylation. It was used to simulate the relations of respiration and ATP formation to extra- and intramitochondrial ATP/ADP ratios under various steady-state conditions. Furthermore, the model equations allowed to compute control coefficients, which quantify the control exerted by different steps on respiration. The distribution of control within mitochondria is demonstrated to depend on the metabolic state of mitochondria and also on the properties of extramitochondrial enzymes involved in ATP turnover. The simulated steady-state data as well as computed control coefficients were found in close agreement with experimental data.
本文提出了一种线粒体能量转导的数学模型。该模型包含氧化磷酸化主要步骤的速率方程。它被用于模拟在各种稳态条件下呼吸作用和ATP生成与线粒体外和线粒体内ATP/ADP比率之间的关系。此外，模型方程能够计算控制系数，该系数量化了不同步骤对呼吸作用施加的控制。结果表明，线粒体内控制的分布取决于线粒体的代谢状态以及参与ATP周转的线粒体外酶的特性。模拟的稳态数据以及计算出的控制系数与实验数据高度吻合。
