Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Trends Biochem Sci. 2018 Mar;43(3):151-153. doi: 10.1016/j.tibs.2017.12.005. Epub 2018 Jan 12.
Oxa1/Alb3/YidC family members promote the insertion of proteins into the mitochondrial inner membrane, the chloroplast thylakoid membrane, and the bacterial plasma membrane. Remarkably, two recent studies identify new Oxa1 homologs that reside in the endoplasmic reticulum (ER) and function in ER membrane protein biogenesis.
Oxa1/Alb3/YidC 家族成员促进蛋白质插入线粒体内膜、叶绿体类囊体膜和细菌质膜。值得注意的是，最近的两项研究确定了新的 Oxa1 同源物，它们位于内质网 (ER) 中，并在 ER 膜蛋白生物发生中发挥作用。
