Department of Medicine, Perlmutter Cancer Center, New York University School of Medicine, New York, New York 10016.
Cold Spring Harb Perspect Med. 2018 Nov 1;8(11):a031484. doi: 10.1101/cshperspect.a031484.
The three human genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.
这三个人类基因编码四种蛋白质，它们作为二元分子开关，通过调节生长和分化信号通路，在致癌作用中发挥核心作用。每一种都受到一组翻译后修饰（PTM）的影响，这些修饰改变了它们的活性或对膜靶向是必需的。催化各种 PTM 的酶是抗 RAS 药物发现的潜在靶点。RAS 蛋白的 PTM 是本综述的重点。
