Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250; and
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
J Immunol. 2018 Jan 15;200(2):422-431. doi: 10.4049/jimmunol.1701019.
Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid cells that have potent immune-suppressive activity. Studies in both mice and humans have demonstrated that MDSC accumulate in most individuals with cancer, where they promote tumor progression, inhibit antitumor immunity, and are an obstacle to many cancer immunotherapies. As a result, there has been intense interest in understanding the mechanisms and in situ conditions that regulate and sustain MDSC, and the mechanisms MDSC use to promote tumor progression. This article reviews the characterization of MDSC and how they are distinguished from neutrophils, describes the suppressive mechanisms used by MDSC to mediate their effects, and explains the role of proinflammatory mediators and the tumor microenvironment in driving MDSC accumulation, suppressive potency, and survival.
髓系来源的抑制性细胞（MDSC）是一群具有强大免疫抑制活性的未成熟髓系细胞。在小鼠和人类中的研究表明，MDSC 在大多数癌症患者中积累，在那里它们促进肿瘤进展、抑制抗肿瘤免疫，并且是许多癌症免疫疗法的障碍。因此，人们强烈关注理解调节和维持 MDSC 的机制和原位条件，以及 MDSC 用于促进肿瘤进展的机制。本文综述了 MDSC 的特征及其与中性粒细胞的区别，描述了 MDSC 用于介导其作用的抑制机制，并解释了促炎介质和肿瘤微环境在驱动 MDSC 积累、抑制效力和存活中的作用。
