髓系来源抑制细胞：它们在癌症和肥胖中的作用。
Myeloid derived-suppressor cells: their role in cancer and obesity.
机构信息
Department of Biological Sciences, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, United States; Department of Pathology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, United States.
出版信息
Curr Opin Immunol. 2018 Apr;51:68-75. doi: 10.1016/j.coi.2018.03.007. Epub 2018 Mar 13.
Abstract
Myeloid-derived suppressor cells (MDSC) are present in most individuals with cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to cancer immunotherapies. Chronic inflammation is characteristic of adipose tissue and is a risk factor for the onset and progression of cancer in obese individuals. Because MDSC accumulate in response to inflammation, it has been hypothesized that one of the mechanisms by which obesity promotes malignancy is through the induction of MDSC. This article reviews the data supporting this hypothesis, the role of leptin and fatty acid metabolism in the induction of MDSC, and the surprising finding that although MDSC promote tumor progression, they are protective against some of the metabolic dysfunction associated with obesity.
摘要
髓系来源的抑制细胞（MDSC）存在于大多数癌症患者体内，它们抑制适应性和先天抗肿瘤免疫，是癌症免疫治疗的障碍。慢性炎症是脂肪组织的特征，也是肥胖个体癌症发病和进展的危险因素。由于 MDSC 是对炎症的反应而积累的，因此有人假设肥胖促进恶性肿瘤的机制之一是通过诱导 MDSC。本文综述了支持这一假说的数据、瘦素和脂肪酸代谢在诱导 MDSC 中的作用，以及一个令人惊讶的发现，即尽管 MDSC 促进肿瘤进展，但它们对与肥胖相关的一些代谢功能障碍具有保护作用。
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本文引用的文献
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