Department of Immunology Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States.
Department of Immunology Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States.
Cell Immunol. 2021 Mar;361:104280. doi: 10.1016/j.cellimm.2020.104280. Epub 2020 Dec 31.
Myeloid derived suppressor cells (MDSC) are a heterogenous population of immature myeloid cells that accumulate in tumor bearing host and migrate to lymphoid organs and tumor tissues. This process is controlled by a set of defined pro-inflammatory cytokines and chemokines, which are upregulated in malignancies. MDSC have strong immunosuppressive potential and constitute a major component of the tumor microenvironment (TME). Tumor cells take advantage of the suppressive mechanisms of MDSC to establish an immunosuppressive TME which inhibits antitumor immune responses thereby promoting cancer progression. An immunosuppressive TME acts as a significant barrier to immunotherapeutic interventions. Pre-clinical and clinical studies have demonstrated that enrichment and activation of MDSC is correlated with tumor progression, recurrence and metastasis. In this review we discuss the potential impact of MDSC on tumor progression and its role as a biomarker of prognostic significance in cancer with a special focus on hepatocellular cancer (HCC).
髓系来源的抑制细胞（MDSC）是一群异质性的未成熟髓系细胞，在肿瘤宿主中积累并迁移到淋巴器官和肿瘤组织。这个过程受一系列定义明确的促炎细胞因子和趋化因子的控制，这些细胞因子在恶性肿瘤中上调。MDSC 具有很强的免疫抑制潜力，构成肿瘤微环境（TME）的主要组成部分。肿瘤细胞利用 MDSC 的抑制机制来建立一个抑制抗肿瘤免疫反应的免疫抑制 TME，从而促进癌症进展。免疫抑制的 TME 是免疫治疗干预的一个重要障碍。临床前和临床研究表明，MDSC 的富集和激活与肿瘤进展、复发和转移相关。在这篇综述中，我们讨论了 MDSC 对肿瘤进展的潜在影响及其作为癌症预后标志物的作用，特别关注肝细胞癌（HCC）。
