Nakahara Soichiro, Matsumoto Mitsuyuki, Ito Hiroyuki, Tajinda Katsunori
Unit 2, Candidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc.
Astellas Research Institute of America LLC.
Biol Pharm Bull. 2018;41(1):138-141. doi: 10.1248/bpb.b17-00643.
Appropriate axonal pathfinding is a necessary step for the function of neuronal circuits. The mossy fibers (MFs) in the hippocampus of CaMKIIα heterozygous knockout (CaMKIIα-hKO) psychiatric model mice project onto not only the stratum lucidum but also the stratum oriens region in the CA3, which is a projection pattern distinct from that in normal mice. Thus, we examined the electrophysiological properties of the MF-CA3 connection in this mutant mouse on field recordings and found a lower synaptic connection. This study suggested that the phenotype of abnormal MF pathfindings could induce aberrant neuronal functions, which may link to cognition and memory.
适当的轴突导向是神经回路发挥功能的必要步骤。在CaMKIIα杂合敲除（CaMKIIα-hKO）精神疾病模型小鼠的海马体中，苔藓纤维（MFs）不仅投射到CA3区的透明层，还投射到其 Oriens 层区域，这是一种与正常小鼠不同的投射模式。因此，我们通过场电位记录研究了该突变小鼠中MF-CA3连接的电生理特性，发现其突触连接较低。本研究表明，MF异常导向的表型可能会诱发异常的神经元功能，这可能与认知和记忆有关。
