Lazar Kristi, Walker Suzanne
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Curr Opin Chem Biol. 2002 Dec;6(6):786-93. doi: 10.1016/s1367-5931(02)00355-1.
It has been known for more than 30 years that Lipid II is an intermediate in peptidoglycan synthesis. Recently, it has become apparent that it is also an important target of numerous antibiotics, including the glycopeptides, the lantibiotics and ramoplanin. It is also utilized by sortases in the construction of Gram-positive cell walls. Recent progress has been made in the synthesis of peptidoglycan intermediates that can be used to study enzymes which make peptidoglycan. These intermediates also enable studies to probe the mechanism of action of a variety of substrate-binding antibiotics.
三十多年来，人们一直知道脂 II 是肽聚糖合成的中间体。最近，越来越明显的是，它也是许多抗生素的重要靶点，包括糖肽类、羊毛硫抗生素和拉莫拉宁。它还被分选酶用于革兰氏阳性细胞壁的构建。在肽聚糖中间体的合成方面取得了新进展，这些中间体可用于研究合成肽聚糖的酶。这些中间体还使人们能够研究各种底物结合抗生素的作用机制。
