Hamo Zohar, Azrad Maya, Nitzan Orna, Sagie Asaf, Tkhawkho Linda, Binyamin Dana, Peretz Avi
Clinical Microbiology Laboratory, The Baruch Padeh Medical Center, Poriya, Tiberias, Israel.
The Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
Front Microbiol. 2017 Dec 19;8:2532. doi: 10.3389/fmicb.2017.02532. eCollection 2017.
To evaluate whether serum Procalcitonin (PCT) at the early stage of infection can serve as a potential biomarker for determining infection (CDI) severity. Fifty-four patients diagnosed with CDI were enrolled in the study. Serum samples were obtained within a median time of 24-48 h of the lab result for presence of . PCT levels were measured by chemiluminescence immunoassay. Demographic, clinical, and prognostic data concerning the patients were retrospectively collected from medical records. The illness severity score was determined according to "Score indices for infection severity." We found that serum PCT levels were significantly higher in patients with moderate disease, compared to patients with mild disease ( = 0.0032). Additionally, PCT was correlated with mortality ( = 0.0002), white blood cell count ( = 0.019), and community-acquired disease ( = 0.0345). Early measurement of PCT may serve as a biomarker for early prediction of CDI severity, which is of great importance due to the high risk of complications and death.
为评估感染早期血清降钙素原（PCT）是否可作为确定艰难梭菌感染（CDI）严重程度的潜在生物标志物。本研究纳入了54例诊断为CDI的患者。在实验室结果显示存在[具体物质或情况未明确]后的中位时间24 - 48小时内采集血清样本。采用化学发光免疫分析法测定PCT水平。有关患者的人口统计学、临床和预后数据均从病历中进行回顾性收集。根据“感染严重程度评分指标”确定疾病严重程度评分。我们发现，与轻度疾病患者相比，中度疾病患者的血清PCT水平显著更高（P = 0.0032）。此外，PCT与死亡率（P = 0.0002）、白细胞计数（P = 0.019）以及社区获得性疾病（P = 0.0345）相关。早期检测PCT可作为早期预测CDI严重程度的生物标志物，鉴于并发症和死亡风险较高，这一点至关重要。
