Bo Xiaobo, Wang Jie, Fu Qiang, Wang Yueqi, Liu Houbao, Xu Jiejie
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Oncotarget. 2017 Jul 27;8(65):108548-108555. doi: 10.18632/oncotarget.19625. eCollection 2017 Dec 12.
Abnormal expression of Stathmin 1(STMN1) plays an important role in the proliferation and migration of gallbladder carcinoma (GBC). The purpose of current study is to investigate the prognostic significance of STMN1 in GBC patients after surgery.
STMN1 expression was evaluated with immunohistochemistry (IHC) on tissue microarrays from 70 GBC patients from a single institution between 2009 and 2013. The correlation between STMN1 expression and clinicopathological profiles and the prognosis was statistically inspected.
High expression of STMN1 in tumoral tissue was associated with poor tumor differentiation (<0.001), lymph node metastasis (=0.028), advanced TNM stage (=0.011) and short overall survival (<0.001). Cox multivariate analysis identified the STMN1 expression as an independent prognostic factor. Integrating STMN1 expression with current TNM staging system generate a better clinical predictive model for GBC. Moreover, the postoperative adjuvant chemotherapy (ACT) showed significant benefit in TNM III- IV stage patients with low STMN1 expression.
STMN1 might be an independent adverse prognostic factor in GBC patients after surgery, which could be combined with TNM staging system to improve the predictive accuracy for overall survival. Low expression of STMN1 stratified a subgroup of advanced GBC patients who could benefit from ACT.
Stathmin 1（STMN1）的异常表达在胆囊癌（GBC）的增殖和迁移中起重要作用。本研究旨在探讨STMN1在GBC患者术后的预后意义。
采用免疫组织化学（IHC）方法对2009年至2013年间来自单一机构的70例GBC患者的组织芯片进行STMN1表达评估。对STMN1表达与临床病理特征及预后之间的相关性进行统计学检验。
肿瘤组织中STMN1的高表达与肿瘤低分化（<0.001）、淋巴结转移（=0.028）、TNM分期较晚（=0.011）及总生存期较短（<0.001）相关。Cox多因素分析确定STMN1表达为独立的预后因素。将STMN1表达与现行TNM分期系统相结合，可为GBC建立更好的临床预测模型。此外，术后辅助化疗（ACT）对STMN1低表达的TNM III-IV期患者显示出显著益处。
STMN1可能是GBC患者术后独立的不良预后因素，可与TNM分期系统相结合以提高总生存期的预测准确性。STMN1低表达可将一部分晚期GBC患者分层出来，这些患者可从ACT中获益。
