急性淋巴细胞白血病中的一个亚二倍体克隆及其复制品。
A hypodiploid clone and its duplicate in acute lymphoblastic leukemia.
作者信息
Shabtai F, Lewinski U H, Har-Zahav L, Gafter U, Halbrecht I, Djaldetti M
出版信息
Am J Clin Pathol. 1979 Dec;72(6):1018-24. doi: 10.1093/ajcp/72.6.1018.
Examination of the bone marrow of a 63-year-old man who had acute lymphoblastic leukemia revealed a population of cells with 32 chromosomes and another population with 64 chromosomes, the karyotypical exact duplicate of the first clone. The karyotypic evolution was studied and the findings compared with those described in two similar cases previously reported. It is postulated that severe hypodiploidy is associated with reduced capability of cellular survival, promoting a strong tendency for duplication.
对一名患有急性淋巴细胞白血病的63岁男性的骨髓进行检查发现，一群细胞有32条染色体，另一群细胞有64条染色体，后者是第一个克隆群的核型精确复制品。对核型演变进行了研究，并将结果与之前报道的两个类似病例中所描述的结果进行了比较。据推测，严重亚二倍体与细胞存活能力降低有关，从而促使出现强烈的复制倾向。
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