Landscape of genomic alterations in hepatocellular carcinoma: current knowledge and perspectives for targeted therapies.
作者信息
Bévant Kévin, Coulouarn Cédric
机构信息
Inserm, Inra, Univ Rennes, UMR 1241, Nutrition Metabolisms and Cancer, Rennes, France.
出版信息
Hepatobiliary Surg Nutr. 2017 Dec;6(6):404-407. doi: 10.21037/hbsn.2017.10.02.
Abstract
摘要
相似文献
1
Landscape of genomic alterations in hepatocellular carcinoma: current knowledge and perspectives for targeted therapies.肝细胞癌基因组改变全景：靶向治疗的当前认知与展望
Hepatobiliary Surg Nutr. 2017 Dec;6(6):404-407. doi: 10.21037/hbsn.2017.10.02.
2
The mutational landscape of hepatocellular carcinoma.肝细胞癌的突变图谱
Clin Mol Hepatol. 2015 Sep;21(3):220-9. doi: 10.3350/cmh.2015.21.3.220. Epub 2015 Sep 30.
3
Targeted genomic landscape of metastases compared to primary tumours in clear cell metastatic renal cell carcinoma.透明细胞转移性肾细胞癌转移灶与原发灶的靶向基因组图谱比较。
Br J Cancer. 2018 May;118(9):1238-1242. doi: 10.1038/s41416-018-0064-3. Epub 2018 Apr 20.
4
Spectrum of genomic alterations in FGFR3: current appraisal of the potential role of FGFR3 in advanced urothelial carcinoma.FGFR3基因改变谱：FGFR3在晚期尿路上皮癌中潜在作用的当前评估
BJU Int. 2016 Nov;118(5):681-691. doi: 10.1111/bju.13552. Epub 2016 Jul 7.
5
Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for targeted therapies.晚期胃癌病例的前瞻性综合基因组分析揭示了频繁的临床相关基因组改变和靶向治疗的新途径。
Oncologist. 2015 May;20(5):499-507. doi: 10.1634/theoncologist.2014-0378. Epub 2015 Apr 16.
6
Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers.原发性肝癌的基因组分析与代谢稳态
Trends Mol Med. 2018 Apr;24(4):395-411. doi: 10.1016/j.molmed.2018.02.006. Epub 2018 Mar 9.
7
[New perspectives for radiosensitization in hepatocellular carcinoma: a review of mechanisms involved in liver oncogenesis].
Cancer Radiother. 2011 Feb;15(1):32-8. doi: 10.1016/j.canrad.2010.11.008. Epub 2011 Jan 14.
8
Systemic Management for Advanced Hepatocellular Carcinoma: A Review of the Molecular Pathways of Carcinogenesis, Current and Emerging Therapies, and Novel Treatment Strategies.晚期肝细胞癌的系统性治疗：致癌分子通路、现有及新兴疗法综述，以及新型治疗策略。
Dig Dis Sci. 2019 Apr;64(4):1016-1029. doi: 10.1007/s10620-019-05582-x.
9
The biology of Hepatocellular carcinoma: implications for genomic and immune therapies.肝细胞癌的生物学特性：对基因组和免疫治疗的启示。
Mol Cancer. 2017 Aug 30;16(1):149. doi: 10.1186/s12943-017-0712-x.
10
Hepatocellular carcinoma: molecular and genomic guideline for the clinician.肝细胞癌：临床医生的分子和基因组指南。
Clin Liver Dis. 2011 May;15(2):307-21, vii-x. doi: 10.1016/j.cld.2011.03.010.
引用本文的文献
1
Pathogenesis and Current Treatment Strategies of Hepatocellular Carcinoma.肝细胞癌的发病机制与当前治疗策略
Biomedicines. 2022 Dec 9;10(12):3202. doi: 10.3390/biomedicines10123202.
2
Comprehensive Analysis Identified Mutation-Gene Signature Impacts the Prognosis Through Immune Function in Hepatocellular Carcinoma.综合分析确定突变基因特征通过免疫功能影响肝细胞癌的预后。
Front Oncol. 2022 Mar 4;12:748557. doi: 10.3389/fonc.2022.748557. eCollection 2022.
3
The Curious Case of the HepG2 Cell Line: 40 Years of Expertise.《HepG2 细胞系的奇异案例：40 年的专业知识》。
Int J Mol Sci. 2021 Dec 4;22(23):13135. doi: 10.3390/ijms222313135.
4
DNA Methylation of TGFβ Target Genes: Epigenetic Control of TGFβ Functional Duality in Liver Cancer.TGFβ 靶基因的 DNA 甲基化：肝癌中 TGFβ 功能双重性的表观遗传调控。
Cells. 2021 Aug 26;10(9):2207. doi: 10.3390/cells10092207.
5
Ahypoxia-related signature enhances the prediction of the prognosis in hepatocellular carcinoma patients and correlates with sorafenib treatment response.一种缺氧相关特征增强了对肝细胞癌患者预后的预测，并与索拉非尼治疗反应相关。
Am J Transl Res. 2020 Dec 15;12(12):7762-7781. eCollection 2020.
6
SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.SLMP53-2通过热休克蛋白70（Hsp70）恢复突变型p53的野生型样功能：在肝细胞癌中具有前景的活性。
Cancers (Basel). 2019 Aug 10;11(8):1151. doi: 10.3390/cancers11081151.
7
The role of exosomes in tumor immunity.外泌体在肿瘤免疫中的作用。
Ann Transl Med. 2018 Dec;6(Suppl 2):S116. doi: 10.21037/atm.2018.12.03.
本文引用的文献
1
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.肝细胞癌的综合与整合基因组特征分析
Cell. 2017 Jun 15;169(7):1327-1341.e23. doi: 10.1016/j.cell.2017.05.046.
2
Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma.整合基因组分析确定人类肝细胞癌的核心转录特征
Cancer Res. 2016 Nov 1;76(21):6374-6381. doi: 10.1158/0008-5472.CAN-16-1559. Epub 2016 Sep 12.
3
Genetic profiling of hepatocellular carcinoma using next-generation sequencing.使用下一代测序技术对肝细胞癌进行基因谱分析。
J Hepatol. 2016 Nov;65(5):1031-1042. doi: 10.1016/j.jhep.2016.05.035. Epub 2016 Jun 2.
4
Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.CTNNB1 基因突变的表型-基因型相关性揭示了与肝肿瘤进展相关的不同 β-连环蛋白活性。
Hepatology. 2016 Dec;64(6):2047-2061. doi: 10.1002/hep.28638. Epub 2016 Jun 11.
5
Long Noncoding RNAs in Cancer Pathways.癌症通路中的长链非编码RNA
Cancer Cell. 2016 Apr 11;29(4):452-463. doi: 10.1016/j.ccell.2016.03.010.
6
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.肝细胞癌的遗传景观和生物标志物。
Gastroenterology. 2015 Oct;149(5):1226-1239.e4. doi: 10.1053/j.gastro.2015.05.061. Epub 2015 Jun 20.
7
Advances in targeted therapies for hepatocellular carcinoma in the genomic era.基因组时代肝细胞癌的靶向治疗进展。
Nat Rev Clin Oncol. 2015 Jul;12(7):408-24. doi: 10.1038/nrclinonc.2015.103. Epub 2015 Jun 9.
8
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.肝细胞癌的外显子组测序鉴定出新的突变特征和潜在治疗靶点。
Nat Genet. 2015 May;47(5):505-511. doi: 10.1038/ng.3252. Epub 2015 Mar 30.
9
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.跨种族肝细胞癌基因组的突变特征。
Nat Genet. 2014 Dec;46(12):1267-73. doi: 10.1038/ng.3126. Epub 2014 Nov 2.
10
Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways.混合型肝细胞癌-胆管细胞癌具有祖细胞特征，并激活了 Wnt 和 TGFβ 信号通路。
Carcinogenesis. 2012 Sep;33(9):1791-6. doi: 10.1093/carcin/bgs208. Epub 2012 Jun 13.
Zotero 插件