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The role of exosomes in tumor immunity.

作者信息

Yang Huayu, Sun Lejia, Mao Yilei

机构信息

Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing 100730, China.

出版信息

Ann Transl Med. 2018 Dec;6(Suppl 2):S116. doi: 10.21037/atm.2018.12.03.

DOI:10.21037/atm.2018.12.03
PMID:30740437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6330635/
Abstract
摘要

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The role of exosomes in tumor immunity.外泌体在肿瘤免疫中的作用。
Ann Transl Med. 2018 Dec;6(Suppl 2):S116. doi: 10.21037/atm.2018.12.03.
2
Functions of Exosomes in the Triangular Relationship between the Tumor, Inflammation, and Immunity in the Tumor Microenvironment.外泌体在肿瘤微环境中肿瘤、炎症和免疫的三角关系中的作用。
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Exosomes derived from Rab27a‑overexpressing tumor cells elicit efficient induction of antitumor immunity.Rab27a 过表达肿瘤细胞衍生的外泌体引发有效的抗肿瘤免疫。
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Umbilical cord blood-derived dendritic cells loaded with BGC823 tumor antigens and DC-derived exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumor immunity in vitro and in vivo.负载BGC823肿瘤抗原的脐带血来源树突状细胞和树突状细胞来源的外泌体在体外和体内均可刺激有效的细胞毒性T淋巴细胞反应和抗肿瘤免疫。
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5
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Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy.外泌体在化疗过程中抑制抗肿瘤免疫。
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The functions and clinical applications of tumor-derived exosomes.肿瘤来源外泌体的功能及临床应用
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Exosomes in cancer development, metastasis, and immunity.外泌体与癌症的发生、转移和免疫。
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Overexpressed Tumor Suppressor Exosomal miR-15a-5p in Cancer Cells Inhibits PD1 Expression in CD8+T Cells and Suppresses the Hepatocellular Carcinoma Progression.癌细胞中过表达的肿瘤抑制性外泌体miR-15a-5p抑制CD8+T细胞中PD1的表达并抑制肝细胞癌进展。
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Vaccines (Basel). 2020 Nov 19;8(4):699. doi: 10.3390/vaccines8040699.

本文引用的文献

1
Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer.肿瘤相关巨噬细胞释放的外泌体转移 miRNA，导致上皮性卵巢癌中 Treg/Th17 细胞失衡。
Cancer Immunol Res. 2018 Dec;6(12):1578-1592. doi: 10.1158/2326-6066.CIR-17-0479. Epub 2018 Nov 5.
2
Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity.脑肿瘤起始细胞向外分泌与外泌体相关的腱生蛋白-C以抑制T细胞活性。
Oncoimmunology. 2018 Aug 6;7(10):e1478647. doi: 10.1080/2162402X.2018.1478647. eCollection 2018.
3
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.外泌体 PD-L1 有助于免疫抑制，并与抗 PD-1 反应相关。
Nature. 2018 Aug;560(7718):382-386. doi: 10.1038/s41586-018-0392-8. Epub 2018 Aug 8.
4
Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis.缺氧肿瘤衍生的外泌体 miR-301a 通过 PTEN/PI3Kγ 介导 M2 巨噬细胞极化促进胰腺癌转移。
Cancer Res. 2018 Aug 15;78(16):4586-4598. doi: 10.1158/0008-5472.CAN-17-3841. Epub 2018 Jun 7.
5
Tumor exosomes block dendritic cells maturation to decrease the T cell immune response.肿瘤外泌体阻止树突状细胞成熟，从而减少 T 细胞免疫反应。
Immunol Lett. 2018 Jul;199:36-43. doi: 10.1016/j.imlet.2018.05.002. Epub 2018 May 22.
6
Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways.缺氧诱导的脑胶质瘤外泌体通过髓源抑制性细胞通过 miR-10a/Rora 和 miR-21/Pten 通路发挥免疫抑制作用。
Oncogene. 2018 Aug;37(31):4239-4259. doi: 10.1038/s41388-018-0261-9. Epub 2018 May 1.
7
The day will come to treat HCC in a drugstore?在药店治疗肝癌的日子会到来吗？
Hepatobiliary Surg Nutr. 2017 Dec;6(6):420-423. doi: 10.21037/hbsn.2017.07.09.
8
Extracellular vesicles in bile: a game changer in the diagnosis of indeterminate biliary stenoses?胆汁中的细胞外囊泡：不确定型胆管狭窄诊断的变革因素？
Hepatobiliary Surg Nutr. 2017 Dec;6(6):408-410. doi: 10.21037/hbsn.2017.10.01.
9
Landscape of genomic alterations in hepatocellular carcinoma: current knowledge and perspectives for targeted therapies.肝细胞癌基因组改变全景：靶向治疗的当前认知与展望
Hepatobiliary Surg Nutr. 2017 Dec;6(6):404-407. doi: 10.21037/hbsn.2017.10.02.
10
Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.肿瘤来源的外泌体通过HSP72/HSP105-TLR2/TLR4途径影响树突状细胞，促进肿瘤转移。
Oncoimmunology. 2017 Aug 18;6(12):e1362527. doi: 10.1080/2162402X.2017.1362527. eCollection 2017.