The role of exosomes in tumor immunity.
作者信息
Yang Huayu, Sun Lejia, Mao Yilei
机构信息
Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing 100730, China.
出版信息
Ann Transl Med. 2018 Dec;6(Suppl 2):S116. doi: 10.21037/atm.2018.12.03.
Abstract
摘要
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本文引用的文献
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Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer.肿瘤相关巨噬细胞释放的外泌体转移 miRNA，导致上皮性卵巢癌中 Treg/Th17 细胞失衡。
Cancer Immunol Res. 2018 Dec;6(12):1578-1592. doi: 10.1158/2326-6066.CIR-17-0479. Epub 2018 Nov 5.
2
Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity.脑肿瘤起始细胞向外分泌与外泌体相关的腱生蛋白-C以抑制T细胞活性。
Oncoimmunology. 2018 Aug 6;7(10):e1478647. doi: 10.1080/2162402X.2018.1478647. eCollection 2018.
3
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.外泌体 PD-L1 有助于免疫抑制，并与抗 PD-1 反应相关。
Nature. 2018 Aug;560(7718):382-386. doi: 10.1038/s41586-018-0392-8. Epub 2018 Aug 8.
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Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis.缺氧肿瘤衍生的外泌体 miR-301a 通过 PTEN/PI3Kγ 介导 M2 巨噬细胞极化促进胰腺癌转移。
Cancer Res. 2018 Aug 15;78(16):4586-4598. doi: 10.1158/0008-5472.CAN-17-3841. Epub 2018 Jun 7.
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Immunol Lett. 2018 Jul;199:36-43. doi: 10.1016/j.imlet.2018.05.002. Epub 2018 May 22.
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Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.肿瘤来源的外泌体通过HSP72/HSP105-TLR2/TLR4途径影响树突状细胞，促进肿瘤转移。
Oncoimmunology. 2017 Aug 18;6(12):e1362527. doi: 10.1080/2162402X.2017.1362527. eCollection 2017.
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