Shi Zhen-Zhen, Fang Sheng-Tao, Miao Feng-Ping, Ji Nai-Yun
a Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , Yantai , China.
b University of Chinese Academy of Sciences , Beijing , China.
Nat Prod Res. 2018 Nov;32(21):2523-2528. doi: 10.1080/14786419.2017.1423312. Epub 2018 Jan 9.
Two new tricycloalternarene-type meroterpenes, 17-O-methyltricycloalternarene D (1) and methyl nortricycloalternarate (4), and two known congeners, TCA D (2) and TCA 1b (3), were isolated from the culture of a marine red alga-epiphytic fungal strain (k21-1) of Alternaria alternata. The planar structures and relative configurations of these two new compounds were unequivocally identified by a combination of 1D/2D NMR, UV, IR, and mass spectra and by comparison with literature data, and the absolute configurations were assigned by analysis of ECD spectra. Compounds 1-4 were evaluated for growth inhibition of four marine plankton species, but they appeared weak or moderate to inhibit them.
从链格孢的一种海洋红藻附生真菌菌株（k21-1）的培养物中分离出两种新的三环交替芳烃型半萜，17-O-甲基三环交替芳烃D（1）和甲基降三环交替芳烃（4），以及两种已知的同系物，三环交替芳烃D（2）和三环交替芳烃1b（3）。通过一维/二维核磁共振、紫外、红外和质谱联用，并与文献数据进行比较，明确鉴定了这两种新化合物的平面结构和相对构型，并通过电子圆二色光谱分析确定了其绝对构型。对化合物1-4进行了四种海洋浮游生物生长抑制活性评估，但它们对其生长的抑制作用较弱或中等。
