Yantai Institute of Coastal Zone Research, Center for Ocean Mega-Science, Chinese Academy of Sciences, Yantai 264003, People's Republic of China.
Chemistry and Chemical Engineering College, Yantai University, Yantai 264005, People's Republic of China.
J Nat Prod. 2021 Jun 25;84(6):1763-1771. doi: 10.1021/acs.jnatprod.1c00021. Epub 2021 May 25.
Two new meroterpenoids, aspermeroterpenes D and E ( and ), two new ophiobolin-type sesterterpenoids, the C-18 epimers of 18,19-dihydro-18-methoxy-19-hydroxyophiobolin P ( and ), and two new drimane-type sesquiterpenoids, 3-hydroxystrobilactone A () and 6--strobilactone A (), along with 11 known terpenoids (- and -) were isolated from the cultures of the algicolous fungus sp. RR-YLW-12, derived from the red alga . The structures and relative configurations of new compounds were established by detailed spectroscopic analysis of NMR and HRMS experiments, and the absolute configurations were assigned by X-ray diffraction experiments and comparison of their experimental and calculated ECD spectra. Compound features a rare 6/6/6/6/5 pentacyclic system with a meroterpenoid skeleton, and the structure of terretonin E () was revised in this study. Compound showed significant inhibitory activities against three microalgae, , , and , with IC values of 10.5, 5.2, and 3.1 μg/mL, respectively.
从红藻 中分离得到一株附生真菌 sp. RR-YLW-12 的培养物，从中分离得到两个新的倍半萜 meroterpenoids，aspermeroterpenes D 和 E（ 和 ），两个新的 ophiobolin 型甾体二萜，C-18 差向异构体 18,19-二氢-18-甲氧基-19-羟基ophiobolin P（ 和 ），以及两个新的 drimane 型倍半萜，3-羟基strobilactone A（）和 6--strobilactone A（），同时还分离得到了 11 种已知的萜类化合物（- 和 -）。新化合物的结构和相对构型通过 NMR 和 HRMS 实验的详细光谱分析确定，绝对构型通过 X 射线衍射实验和比较其实验和计算的 ECD 光谱确定。化合物 具有罕见的 6/6/6/6/5 五环体系和 meroterpenoid 骨架，本研究中对 terretonin E（）的结构进行了修订。化合物 对三种微藻 、 、 和 表现出显著的抑制活性，IC 值分别为 10.5、5.2 和 3.1 μg/mL。
