从真菌交替单端孢 JJY-32 中分离得到细胞毒性倍半萜。
Cytotoxic Meroterpenoids from the Fungus Alternaria sp. JJY-32.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China.
Sino Silliker Testing Services Co., Ltd, Qingdao, 266011, P. R. China.
出版信息
Chem Biodivers. 2020 Jul;17(7):e2000226. doi: 10.1002/cbdv.202000226. Epub 2020 Jul 7.
Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY-32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dichroism (ECD) spectral analyses, and biosynthesis consideration. Tricycloalternarene X showed cytotoxicity against the HL-60 and HO8910 cells with IC values of 7.54 and 20.32 μm.
两种新的倍半萜类化合物，三环交替烯 X 和 Y，以及一种已知的倍半萜类化合物，三环交替烯 I，从真菌交替曲霉菌 JJY-32 中分离得到。通过综合光谱数据、电子圆二色性（ECD）光谱分析和生物合成考虑，确定了结构包括绝对构型。三环交替烯 X 对 HL-60 和 HO8910 细胞具有细胞毒性，IC 值分别为 7.54 和 20.32 μm。
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