Franco-Robles Elena, Ramírez-Emiliano Joel, López Mercedes G
a Departamento de Veterinaria y Zootecnia , División de Ciencias de la Vida, Campus Irapuato-Salamanca, Universidad de Guanajuato , León , México.
b Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León , Universidad de Guanajuato , Leon de los Aldama , México.
Nat Prod Res. 2019 May;33(10):1527-1530. doi: 10.1080/14786419.2017.1423297. Epub 2018 Jan 9.
Obesity is currently a public health problem worldwide. Recently, non-reducing carbohydrates, that include (2→1) and (2→6) linkages in their structure, have been of particular interest in the field of obesity because they are involved in lipid metabolism. Some of these are agave fructans (AF) and oligofructose (OF). In this study, we evaluated both AF and OF on oxidative stress (OS) markers in the brain of overweight mice (OM). AF and OF decreased TBARS levels and carbonyls at different levels in hippocampus (HP), frontal cortex (FC) and cerebellum (CB) of OM. The results indicated that fructans may have anti-oxidative potential and can be used as an alternative treatment for the prevention of the consequences of this pathology.
肥胖目前是一个全球性的公共卫生问题。最近，结构中包含（2→1）和（2→6）连接键的非还原碳水化合物在肥胖领域引起了特别关注，因为它们参与脂质代谢。其中一些是龙舌兰果聚糖（AF）和低聚果糖（OF）。在本研究中，我们评估了AF和OF对超重小鼠（OM）大脑氧化应激（OS）标志物的影响。AF和OF降低了OM小鼠海马体（HP）、额叶皮质（FC）和小脑（CB）中不同水平的硫代巴比妥酸反应物（TBARS）含量和羰基含量。结果表明，果聚糖可能具有抗氧化潜力，可作为预防该病理后果的替代治疗方法。
