墨西哥龙舌兰果聚糖对食用婴儿配方奶粉的新生儿的影响：一项随机对照试验。
Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial.
作者信息
López-Velázquez Gabriel, Parra-Ortiz Minerva, Mora Ignacio De la Mora-De la, García-Torres Itzhel, Enríquez-Flores Sergio, Alcántara-Ortigoza Miguel Angel, Angel Ariadna González-Del, Velázquez-Aragón José, Ortiz-Hernández Rosario, Cruz-Rubio José Manuel, Villa-Barragán Pablo, Jiménez-Gutiérrez Carlos, Gutiérrez-Castrellón Pedro
机构信息
Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Mexico City 04530, México.
Hospital General de México Dr. Eduardo Liceaga, Mexico City 06726, México.
出版信息
Nutrients. 2015 Oct 29;7(11):8939-51. doi: 10.3390/nu7115442.
BACKGROUND
The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated.
METHODS
This study aimed to demonstrate the efficacy as prebiotics of Metlin(®) and Metlos(®) in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes.
RESULTS
There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin(®) and Metlos(®).
CONCLUSIONS
Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption.
TRIAL REGISTRATION
ClinicalTrials.gov, NCT 01251783.
背景
由于益生元对健康有益，其在全球的消费量正不断增加。利用本地植物生产出更好的益生元，为增强弱势群体的营养效果带来了可能。源自龙舌兰植物的果聚糖已在动物模型中证明了其作为益生元的安全性和有效性。最近，还证明了从龙舌兰中提取的两种果聚糖（Metlin®和Metlos®）对人体的安全性。
方法
本研究旨在通过一项采用试点研究设计的随机、双盲、对照试验，证明Metlin®和Metlos®在新生儿中作为益生元的功效。在健康婴儿20±7日龄和3月龄时采集生物样本。功效结果包括对免疫反应、血清铁蛋白、C反应蛋白、骨代谢和肠道细菌变化的影响。
结果
仅喂食婴儿配方奶粉的婴儿组与喂食添加了Metlin®和Metlos®的配方奶粉的婴儿组之间存在统计学显著差异。
结论
我们的结果支持Metlin®和Metlos®作为益生元对人体的功效，并为推荐食用它们奠定了基础。
试验注册
ClinicalTrials.gov，NCT 01251783。
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