Unit of Medical and Pharmaceutical Biotechnology, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C. (CIATEJ), Normalistas 800, 44270, Guadalajara, State of Jalisco, Mexico.
Department of Biochemistry, University of Alberta, 474 Medical Sciences Building, Edmonton, AB, T6G 2R3, Canada.
Plant Foods Hum Nutr. 2018 Mar;73(1):34-39. doi: 10.1007/s11130-018-0654-5.
Obesity affects millions of people worldwide, constituting a public health problem associated with premature mortality. Agave fructans decrease fat mass, body and liver weight, and generate satiety in rodents. In the present study the effects of agave fructans on weight control, lipid profile, and physical tolerability were evaluated in obese people. Twenty-eight obese volunteers were randomly divided into two groups. In the first group, 96 mg/bw of agave fructans was administered for 12 weeks; in the second group, maltodextrin as a placebo was administered for 12 weeks. All participants consumed a low-calorie diet of 1500 kcal/day. Anthropometric and biochemical measurements were taken at baseline and at the end of the study. The body mass index (BMI) of the agave fructans treated group was reduced significantly from the baseline to the final measurements. Hip and waist circumferences decreased statistically in both groups. A decrease of 10% in total body fat was observed in the agave fructans treated group, resulting in a statistically significant difference in the final versus baseline measurements between the Agave fructans treated group and the placebo treated group. Triglycerides were reduced significantly in the agave fructans treated group. Glucose values did not change in either group. Agave fructans intake was safe and well tolerated throughout the study. The results showed that the ingestion of agave fructans enhanced the decrease in BMI, the decrease in total body fat, and the decrease in triglycerides in obese individuals who consume a low-calorie diet.
肥胖影响着全球数以百万计的人，是与过早死亡相关的公共健康问题。龙舌兰果糖可减少脂肪量、体重和肝脏重量，并在啮齿动物中产生饱腹感。在本研究中，评估了龙舌兰果糖对肥胖人群的体重控制、血脂谱和身体耐受性的影响。将 28 名肥胖志愿者随机分为两组。在第一组中，96mg/bw 的龙舌兰果糖被给予 12 周；在第二组中，给予麦芽糊精作为安慰剂 12 周。所有参与者均摄入 1500 卡路里/天的低热量饮食。在基线和研究结束时进行人体测量和生化测量。龙舌兰果糖治疗组的体重指数（BMI）从基线到最终测量值显著降低。两组的臀围和腰围均有统计学上的降低。龙舌兰果糖治疗组的总体体脂减少了 10%，这导致龙舌兰果糖治疗组与安慰剂治疗组之间的最终与基线测量值之间存在统计学上的显著差异。龙舌兰果糖治疗组的甘油三酯显著降低。两组的血糖值均无变化。在整个研究过程中，龙舌兰果糖的摄入是安全且耐受良好的。结果表明，在摄入低热量饮食的肥胖个体中，龙舌兰果糖的摄入增强了 BMI 的降低、总体体脂的降低和甘油三酯的降低。
