Shukla Vaibhav, Fatima Jalees, Chaudhary Saurabh, Ali Mohsin, Mishra Ishan
Professor.
Resident, Era Medical College, Lucknow, Uttar Pradesh.
J Assoc Physicians India. 2017 Sep;65(9):18-22.
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide rapidly and is regarded as the hepatic manifestation of metabolic syndrome. The present study was undertaken to study the endothelial dysfunction by flow mediated vasodilatation in NAFLD patients.
MATERIAL & METHODS: 32 cases and 16 age and sex matched controls were included in the study. Flow mediated vasodilatation of the brachial artery was studied in both cases and controls. Anthropometric, clinical and biochemical assessment was also done.
It was found that NAFLD patients had a significant endothelial dysfunction as assessed by flow mediated vasodilatation as compared with controls. Percentage change in FMD among NAFLD patients (13.54±3.65%) was found to be lower than that in controls (16.84±4.61%) and difference was found to be statistically significant (p 0.010).
From the present study it can be concluded that NAFLD patients have significant endothelial dysfunction even in the absence of traditional risk factors of cardiovascular disease.
非酒精性脂肪性肝病（NAFLD）在全球范围内的患病率正在迅速上升，被视为代谢综合征的肝脏表现。本研究旨在通过血流介导的血管舒张来研究NAFLD患者的内皮功能障碍。
本研究纳入了32例患者以及16例年龄和性别匹配的对照。对病例组和对照组均进行了肱动脉血流介导的血管舒张研究。还进行了人体测量、临床和生化评估。
发现与对照组相比，通过血流介导的血管舒张评估，NAFLD患者存在明显的内皮功能障碍。NAFLD患者的血流介导的血管舒张百分比变化（13.54±3.65%）低于对照组（16.84±4.61%），差异具有统计学意义（p = 0.010）。
从本研究可以得出结论，即使没有心血管疾病的传统危险因素，NAFLD患者也存在明显的内皮功能障碍。
