Saxena S, Jha P, Farooq A
Immunol Invest. 1985 Jun;14(3):255-69. doi: 10.3109/08820138509076149.
Immunosuppressive property of normal human seminal plasma has been demonstrated on various in vitro immune parameters such as, blast transformation of lymphocytes with Phytohemagglutinin (P), Concanavalin A and Lipopolysaccharide, E & EAC rosette formation and mixed lymphocyte culture. The immunosuppression appears to be a T-cell mediated phenomenon. Analysis of semen samples obtained from 86 donors, comprising azoospermic, oligospermic, normospermic and polyspermic individuals, suggests that immunosuppression of the seminal plasma has no correlation with either the sperm density or the protein content of seminal plasma. The possible implication of the immunosuppressive activity in the development of acquired immuno-deficiency syndrome is also discussed.
正常人类精浆的免疫抑制特性已在多种体外免疫参数上得到证实，如植物血凝素（P）、刀豆球蛋白A和脂多糖刺激淋巴细胞的增殖转化、E及EAC玫瑰花结形成以及混合淋巴细胞培养。这种免疫抑制似乎是一种T细胞介导的现象。对86名供体的精液样本分析，这些供体包括无精子症、少精子症、正常精子症和多精子症个体，结果表明精浆的免疫抑制与精子密度或精浆蛋白含量均无关联。文中还讨论了免疫抑制活性在获得性免疫缺陷综合征发展过程中的可能影响。
