骨骼肌细胞膜兴奋性在正常人体衰老过程中的变化。
Sarcolemmal excitability changes in normal human aging.
机构信息
Department of Neurology, Royal North Shore Hospital, St Leonards, New South Wales, 2065, Australia.
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.
出版信息
Muscle Nerve. 2018 Jun;57(6):981-988. doi: 10.1002/mus.26058. Epub 2018 Feb 2.
INTRODUCTION
The exact mechanisms underlying the loss of skeletal muscle bulk and power with normal human aging are not well established. Recording of muscle velocity recovery cycles (MVRCs) is an in-vivo neurophysiologic technique we employed to assess the impact of age on sarcolemmal excitability.
METHODS
MVRC recordings were obtained from tibialis anterior (n = 74) and rectus femoris (n = 32) muscles in 74 healthy subjects (18-84 years, median age 35 years, interquartile range 29-55 years).
RESULTS
Increasing age was linearly associated with longer muscle relative refractory period (MRRP) and reduced early supernormality (ESN) in both tibialis anterior (MRRP: r = 0.38, P < 0.001; ESN: r = 0.33, P < 0.001) and rectus femoris (MRRP: r = 0.30, P = 0.002; ESN: r = 0.19, P = 0.01) muscles.
DISCUSSION
The results are consistent with progressive depolarization of the resting sarcolemmal potential with normal aging. This may be an important mechanism in explaining age-related muscle decline. Muscle Nerve 57: 981-988, 2018.
简介
正常人类衰老过程中骨骼肌体积和力量丧失的确切机制尚未完全确定。我们采用记录肌动速度恢复循环（MVRC）的方法来评估年龄对肌膜兴奋性的影响，这是一种活体神经生理技术。
方法
我们从 74 名健康受试者（年龄 18-84 岁，中位年龄 35 岁，四分位间距 29-55 岁）的胫骨前肌（n = 74）和股直肌（n = 32）中获得 MVRC 记录。
结果
随着年龄的增长，胫骨前肌（MRRP：r = 0.38，P < 0.001；ESN：r = 0.33，P < 0.001）和股直肌（MRRP：r = 0.30，P = 0.002；ESN：r = 0.19，P = 0.01）的相对不应期（MRRP）延长，早期超兴奋性（ESN）降低，与年龄呈线性相关。
讨论
结果与正常衰老过程中静止肌膜电位的逐渐去极化一致。这可能是解释与年龄相关的肌肉衰退的一个重要机制。肌肉神经 57:981-988,2018。
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