肌肉兴奋性测试：正常数据的年龄和性别依赖性
Muscle excitability testing: Age and sex dependency of normative data.
作者信息
Exl Matthias Thomas, Rodriguez Belén, Ng Karl, Tan Stella Veronica, Howells James, Bostock Hugh, Tankisi Hatice, Z'Graggen Werner J
机构信息
Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Graduate School for Health Science, University of Bern, Bern, Switzerland.
出版信息
Clin Neurophysiol Pract. 2025 Mar 14;10:129-133. doi: 10.1016/j.cnp.2025.03.002. eCollection 2025.
OBJECTIVE
To establish normative data for muscle excitability testing in the tibialis anterior muscle of a healthy population, and to determine their dependence on age and sex.
METHODS
Parameters of muscle velocity recovery cycle recordings with 1, 2 and 5 conditioning stimuli of 197 healthy subjects and frequency ramp recordings of 151 healthy subjects were retrospectively analysed for age and sex differences.
RESULTS
There were no differences by sex and only small age differences were found in healthy subjects older than 60 years for the muscle excitability parameters muscle relative refractory period, early supernormality and latency to the first response in a train at 15 Hz and 30 Hz.
CONCLUSIONS
In this study, based on a large sample of muscle velocity recovery cycle and frequency ramp recordings, we have provided normative data and shown that muscle excitability testing is not influenced by sex, and that age only has an influence from the age of 60 years onwards on parameters reflecting muscle membrane potential.
SIGNIFICANCE
Our results suggest that future studies no longer need to control for sex when using a healthy control group.
目的
建立健康人群胫骨前肌肌肉兴奋性测试的标准数据，并确定其对年龄和性别的依赖性。
方法
回顾性分析197名健康受试者在1次、2次和5次条件刺激下肌肉速度恢复周期记录的参数，以及151名健康受试者的频率斜坡记录，以分析年龄和性别差异。
结果
在健康受试者中，性别之间没有差异，仅在60岁以上的健康受试者中，对于肌肉兴奋性参数肌肉相对不应期、早期超常期以及在15Hz和30Hz频率下一串刺激中第一个反应的潜伏期，发现了较小的年龄差异。
结论
在本研究中，基于大量肌肉速度恢复周期和频率斜坡记录样本，我们提供了标准数据，并表明肌肉兴奋性测试不受性别影响，且年龄仅从60岁起对反映肌膜电位的参数有影响。
意义
我们的结果表明，未来研究在使用健康对照组时无需再考虑性别因素。
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