Department of Dermatology, Bispebjerg University Hospital, 2400, Copenhagen, Denmark.
Department of Dermatology, VU University Medical Centre, 1081, Amsterdam, The Netherlands.
Contact Dermatitis. 2018 Mar;78(3):216-222. doi: 10.1111/cod.12945. Epub 2018 Jan 4.
Only a few clinical trials on hand eczema have included further classification into subtypes, and there is a need for studies evaluating the present classifications.
To examine differences in demographic factors, lifestyle factors and severity between subgroups of hand eczema patients, with a focus on hyperkeratotic hand eczema.
This was a retrospective study including hand eczema patients referred to the outpatient dermatological clinic, Bispebjerg Hospital, between January 2013 and July 2014. The study comprises information on subdiagnoses, treatment and foot eczema from patient files, as well as a follow-up questionnaire.
A total of 120 patients were included, 10 of whom were diagnosed with hyperkeratotic hand eczema. A significantly higher proportion of the patients with hyperkeratotic hand eczema were male (p = 0.002) and received systemic or ultraviolet (UV) treatment (p = 0.026). The frequency of tobacco smoking was significantly higher in patients with hyperkeratotic hand eczema (p = 0.016), as well as in the other subgroups combined (p = 0.049), than in the background population.
Studies evaluating the subdiagnoses of hand eczema are needed, to further validate the classification system, and to provide more detailed information about demographic factors, severity and possible risk factors for different subgroups of hand eczema.
仅有少数手部湿疹的临床试验对亚型进行了进一步分类，因此需要评估目前分类的研究。
研究手部湿疹患者亚组之间在人口统计学因素、生活方式因素和严重程度方面的差异，重点关注角化过度型手部湿疹。
这是一项回顾性研究，纳入了 2013 年 1 月至 2014 年 7 月间在比斯特弗约尔医院皮肤科门诊就诊的手部湿疹患者。研究包括患者病历中的亚诊断、治疗和足癣信息，以及随访问卷。
共纳入 120 例患者，其中 10 例被诊断为角化过度型手部湿疹。角化过度型手部湿疹患者中男性比例显著更高（p = 0.002），且更常接受系统性或紫外线（UV）治疗（p = 0.026）。角化过度型手部湿疹患者的吸烟频率显著更高（p = 0.016），其他亚组患者的吸烟频率也显著更高（p = 0.049），均高于普通人群。
需要评估手部湿疹的亚诊断，以进一步验证分类系统，并提供有关不同手部湿疹亚组的人口统计学因素、严重程度和可能危险因素的更详细信息。
