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日常的生活方式与炎症性皮肤疾病

Daily Lifestyle and Inflammatory Skin Diseases.

机构信息

Department of Dermatology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-Ku, Kitakyushu 807-8555, Japan.

出版信息

Int J Mol Sci. 2021 May 14;22(10):5204. doi: 10.3390/ijms22105204.

Abstract

Throughout life, it is necessary to adapt to the Earth's environment in order to survive. A typical example of this is that the daily Earth cycle is different from the circadian rhythm in human beings; however, the ability to adapt to the Earth cycle has contributed to the development of human evolution. In addition, humans can consume and digest Earth-derived foods and use luxury materials for nutrition and enrichment of their lives, as an adaptation to the Earth's environment. Recent studies have shown that daily lifestyles are closely related to human health; however, less attention has been paid to the fact that obesity due to excessive energy intake, smoking, and alcohol consumption contributes to the development of inflammatory skin diseases. Gluten or wheat protein, smoking and alcohol, sleep disturbance, and obesity drive the helper T (Th)1/Th2/Th17 immune response, whereas dietary fiber and omega-3 fatty acids negatively regulate inflammatory cytokine production. In this review, we have focused on daily lifestyles and the mechanisms involved in the pathogenesis of inflammatory skin diseases.

摘要

在整个生命过程中,为了生存,有必要适应地球环境。一个典型的例子是,地球的日常循环与人类的昼夜节律不同;然而,适应地球周期的能力促进了人类进化的发展。此外,人类可以消耗和消化源自地球的食物,并利用奢侈品来为生活提供营养和丰富,这是对地球环境的一种适应。最近的研究表明,日常生活方式与人类健康密切相关;然而,人们较少关注摄入过多能量、吸烟和饮酒导致肥胖这一事实,这会导致炎症性皮肤病的发展。麸质或小麦蛋白、吸烟和饮酒、睡眠障碍和肥胖会促进辅助性 T(Th)1/Th2/Th17 免疫反应,而膳食纤维和 ω-3 脂肪酸则会负调节炎症细胞因子的产生。在这篇综述中,我们重点讨论了日常生活方式以及炎症性皮肤病发病机制中的相关机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e23/8156947/f5ad483e700b/ijms-22-05204-g001.jpg

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