Agner T, Aalto-Korte K, Andersen K E, Foti C, Gimenéz-Arnau A, Goncalo M, Goossens A, Le Coz C, Diepgen T L
Department of Dermatology, Bispebjerg University Hospital, Copenhagen NV, Denmark.
Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland.
J Eur Acad Dermatol Venereol. 2017 May;31(5):828-832. doi: 10.1111/jdv.14016. Epub 2016 Nov 15.
As for hand eczema, the aetiology of foot eczema is multifactorial and not very well understood. The aim of the present study was to identify factors associated with foot eczema in a cohort of hand eczema patients being classified into different subgroups.
Associations between foot and hand eczema were studied in a cross-sectional design in a cohort of hand eczema patients. Consecutive patients were recruited from nine different European Centres during the period October 2011-September 2012. Data on demographic factors, presence of foot eczema, hand eczema duration and severity, and whether the hand eczema was work-related or not were available, as well as patch-test results.
Of a total of 427 hand eczema patients identified, information on foot eczema was available in 419 patients who were included in the present study. A total of 125 patients (29.8%) had concomitant foot and hand eczema. It was found more often in association with hyperkeratotic hand eczema (P = 0.007) and was less often associated with irritant hand eczema (P < 0.001). However, foot eczema was nevertheless found in 18% of patient with irritant hand eczema and in 25% of patients with occupational hand eczema. Combined foot and hand eczema was associated with more severe and long-standing hand eczema (P < 0.001 and P = 0.004, respectively). Contact allergy was found in 51.8% with no difference between patients with combined foot and hand eczema and patients with hand eczema only.
Occurrence of combined foot and hand eczema is a common finding and not restricted to endogenous hand eczema.
足部湿疹的病因是多因素的，目前尚未完全明确，与手部湿疹类似。本研究旨在确定手部湿疹患者队列中不同亚组足部湿疹的相关因素。
采用横断面设计，对一组手部湿疹患者进行足部与手部湿疹相关性研究。2011年10月至2012年9月期间，从9个不同的欧洲中心招募连续的患者。收集了人口统计学因素、足部湿疹情况、手部湿疹持续时间和严重程度、手部湿疹是否与工作相关的数据，以及斑贴试验结果。
在总共427例确诊的手部湿疹患者中，419例患者有足部湿疹信息并纳入本研究。共有125例患者（29.8%）同时患有足部和手部湿疹。其更常与角化过度型手部湿疹相关（P = 0.007），而与刺激性手部湿疹的相关性较小（P < 0.001）。然而，在18%的刺激性手部湿疹患者和25%的职业性手部湿疹患者中仍发现有足部湿疹。足部和手部湿疹合并症与更严重、病程更长的手部湿疹相关（分别为P < 0.001和P = 0.004）。51.8%的患者存在接触性过敏，足部和手部湿疹合并症患者与仅患有手部湿疹的患者之间无差异。
足部和手部湿疹合并症很常见，并不局限于内源性手部湿疹。
