Zhen Qiang, Gao Li-Na, Wang Ren-Feng, Chu Wei-Wei, Zhang Ya-Xiao, Zhao Xiao-Jian, Lv Bao-Lei, Liu Jia-Bao
Department of Thoracic Surgery, Shijiazhuang No.1 Hospital, Shijiazhuang, Hebei Province, China.
Obstetrical and Reproductive Genetic Department, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Cell Biochem Funct. 2018 Jan;36(1):27-33. doi: 10.1002/cbf.3314. Epub 2018 Jan 7.
Oesophageal cancer (OC) is one of the most fatal malignancies in the world, and chemoresistance restricts the therapeutic outcome of OC. Long noncoding RNA (lncRNA) was reported to play roles in multiple cancer types. Yet, the function of lncRNA in chemoresistance of OC has not been reported. A lncRNA gene, PCAT-1, showed higher expression in OC tissues, especially higher in secondary OC compared with normal mucosa tissues. Overexpression of PCAT-1 increased the proliferation rate and growth of OC cells. Inhibition of PCAT-1 decreased proliferation and growth of OC cells, and increased cisplatin chemosensitivity. In a mouse OC xenograft model, PCAT-1 inhibition repressed OC growth in vivo. Therefore, PCAT-1 may potentially serve as a therapeutic target for treating OC. PCAT-1 promotes development of OC and represses the chemoresistance of OC to cisplatin, and silencing of PCAT-1 may be a therapeutic strategy for treating OC.
食管癌（OC）是全球最致命的恶性肿瘤之一，化疗耐药性限制了OC的治疗效果。据报道，长链非编码RNA（lncRNA）在多种癌症类型中发挥作用。然而，lncRNA在OC化疗耐药中的作用尚未见报道。一种lncRNA基因，即前列腺癌相关转录本1（PCAT-1），在OC组织中表达较高，与正常黏膜组织相比，在继发性OC中表达尤其高。PCAT-1的过表达增加了OC细胞的增殖率和生长。抑制PCAT-1可降低OC细胞的增殖和生长，并增加顺铂化疗敏感性。在小鼠OC异种移植模型中，抑制PCAT-1可在体内抑制OC生长。因此，PCAT-1可能潜在地作为治疗OC的靶点。PCAT-1促进OC的发展并抑制OC对顺铂的化疗耐药性，沉默PCAT-1可能是治疗OC的一种治疗策略。
