Zhang Hanqun, Fang Chunju, Feng Zhiyu, Xia Tingting, Lu Liang, Luo Min, Chen Yanping, Liu Yuncong, Li Yong
Department of Oncology, Guizhou Provincial People's Hospital, Guizhou, China.
Department of Nephrology, Guizhou Provincial People's Hospital, Guizhou, China.
Front Oncol. 2022 May 26;12:896840. doi: 10.3389/fonc.2022.896840. eCollection 2022.
Cervical cancer (CC) is one of the three majors gynecological malignancies, which seriously threatens women's health and life. Radiotherapy (RT) is one of the most common treatments for cervical cancer, which can reduce local recurrence and prolong survival in patients with cervical cancer. However, the resistance of cancer cells to Radiotherapy are the main cause of treatment failure in patients with cervical cancer. Long non-coding RNAs (LncRNAs) are a group of non-protein-coding RNAs with a length of more than 200 nucleotides, which play an important role in regulating the biological behavior of cervical cancer. Recent studies have shown that LncRNAs play a key role in regulating the sensitivity of radiotherapy for cervical cancer. In this review, we summarize the structure and function of LncRNAs and the molecular mechanism of radiosensitivity in cervical cancer, list the LncRNAs associated with radiosensitivity in cervical cancer, analyze their potential mechanisms, and discuss the potential clinical application of these LncRNAs in regulating radiosensitivity in cervical cancer.
宫颈癌（CC）是三大主要妇科恶性肿瘤之一，严重威胁着女性的健康和生命。放射治疗（RT）是宫颈癌最常见的治疗方法之一，可降低局部复发率并延长宫颈癌患者的生存期。然而，癌细胞对放射治疗的抗性是宫颈癌患者治疗失败的主要原因。长链非编码RNA（LncRNAs）是一类长度超过200个核苷酸的非蛋白质编码RNA，在调节宫颈癌的生物学行为中起重要作用。最近的研究表明，LncRNAs在调节宫颈癌放射治疗敏感性方面起关键作用。在本综述中，我们总结了LncRNAs的结构和功能以及宫颈癌放射敏感性的分子机制，列出了与宫颈癌放射敏感性相关的LncRNAs，分析了它们的潜在机制，并讨论了这些LncRNAs在调节宫颈癌放射敏感性方面的潜在临床应用。
