Trozak D J
J Am Acad Dermatol. 1985 Aug;13(2 Pt 1):247-51. doi: 10.1016/s0190-9622(85)70167-3.
Transdermal devices are now marketed for the delivery of systemic medications through the skin. This report confirms delayed hypersensitivity to scopolamine, the active ingredient in Transderm-Scop. Patch testing with structurally related alkaloids suggests the active antigenic site on the scopolamine molecule. The mechanism of drug delivery by the transdermal device is discussed, along with the features that make this an attractive method of drug administration. Dermatologists should be familiar with these devices, since broader future applications can be expected.
透皮给药装置目前已投放市场，用于通过皮肤递送全身性药物。本报告证实了对东莨菪碱（Transderm-Scop中的活性成分）存在迟发型超敏反应。用结构相关生物碱进行斑贴试验提示了东莨菪碱分子上的活性抗原位点。文中讨论了透皮给药装置的给药机制，以及使其成为一种有吸引力的给药方法的特点。皮肤科医生应熟悉这些装置，因为有望在未来得到更广泛的应用。
