Romita Paolo, Foti Caterina, Calogiuri Gianfranco, Cantore Stefania, Ballini Andrea, Dipalma Gianna, Inchingolo Francesco
Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Italy.
Acta Biomed. 2018 Oct 26;90(1):5-10. doi: 10.23750/abm.v90i1.6563.
Transdermal therapeutic systems (TTS) have become a popular method of drug delivery because they allow drugs to be delivered in a rate-controlled manner, avoiding first-pass metabolism and the fluctuating plasma concentrations encountered with oral medications. Unfortunately, TTS may provoke adverse skin reactions as irritating contact dermatitis and allergic contact dermatitis: TTS seem to be ideally suited to produce sensitization because they cause occlusion, irritation, due to the repeated placement of the allergen in the same skin location. Since TTS consist of an adhesive, an active pharmaceutical drug and enhancing agents, sensitization may develop owing to one of these three agents. The purpose of this manuscript is to review known responsible allergens of contact dermatitis due to TTS.
透皮治疗系统（TTS）已成为一种流行的给药方法，因为它们能以速率控制的方式给药，避免首过代谢以及口服药物所出现的血浆浓度波动。不幸的是，TTS可能引发不良皮肤反应，如刺激性接触性皮炎和过敏性接触性皮炎：TTS似乎非常适合引发致敏，因为它们会导致皮肤闭塞、产生刺激，这是由于过敏原反复置于同一皮肤部位所致。由于TTS由一种黏合剂、一种活性药物和增强剂组成，致敏可能由这三种成分之一引起。本手稿的目的是综述已知的由TTS引起的接触性皮炎的相关致敏原。
