Crea F, Fenech A, Smith W, Conti C R, Abela G S
J Am Coll Cardiol. 1985 Nov;6(5):1052-6. doi: 10.1016/s0735-1097(85)80308-9.
Laser recanalization was attempted in thrombosed coronary arteries of 10 dogs. In all dogs a coronary thrombus was obtained by passing a low grade electrical current through a guide wire advanced into the artery. Recanalization was then attempted using an argon laser with energy levels ranging from 3 to 30 J. In six dogs a 140 micron core optical fiber was positioned proximal to the thrombus and lasing was done during fiber advancement. The thrombosed artery was recanalized in one dog, perforated in four and neither recanalized nor perforated in one. In the remaining four dogs a steerable guide wire was advanced across the thrombus and a catheter was passed over the guide wire and exchanged for a 200 micron core optical fiber. After fiber withdrawal, mechanical recanalization without lasing was performed in one of the four dogs. In the remaining three dogs, both the fiber and the catheter were again advanced distal to the thrombus and lasing was done during withdrawal; this caused coronary perforation in all dogs. Laser recanalization of thrombosed coronary arteries in dogs using currently available techniques is feasible but results in a very high incidence of perforation.
对10只狗的血栓性冠状动脉尝试进行激光再通术。在所有狗中，通过将低强度电流通过推进到动脉中的导丝来形成冠状动脉血栓。然后使用能量水平在3至30焦耳之间的氩激光尝试进行再通。在6只狗中，将一根140微米芯的光纤放置在血栓近端，并在光纤推进过程中进行激光照射。1只狗的血栓性动脉再通，4只狗的动脉穿孔，1只狗的动脉既未再通也未穿孔。在其余4只狗中，将一根可操纵导丝推进穿过血栓，然后将导管穿过导丝并换成一根200微米芯的光纤。在4只狗中的1只狗在光纤抽出后进行了无激光照射的机械再通。在其余3只狗中，光纤和导管再次推进到血栓远端，并在抽出过程中进行激光照射；这导致所有狗的冠状动脉穿孔。使用现有技术对狗的血栓性冠状动脉进行激光再通是可行的，但穿孔发生率非常高。
