Marco J, Silvernail P J, Fournial G, Choy D S, Fajadet J, Case R B
Lasers Surg Med. 1985;5(3):291-6. doi: 10.1002/lsm.1900050311.
The potential problem of rethrombosis after laser recanalization was studied in 16 thrombus-occluded canine femoral arteries. Balloon de-endothelialization and thrombin-human blood injection produced adherent, completely occlusive thrombi 4.13 +/- 1.54 cm in length; laser exposure of the thrombi occurred at 18.35 +/- 22.1 hours. The argon laser catheter was introduced via a proximal arteriotomy and a power of 3.83 +/- 0.58 W delivered for 411.3 +/- 296.87 seconds. Follow-up period was 14 days. All arteries were patent immediately after and 14 days following lasing, as demonstrated by angiography. There was no vessel perforation. Seven of the dogs were maintained on aspirin and dipyridamole 4 days before and throughout the study, but there were no differences in thrombus length, laser power, or duration of laser exposure between these dogs and those receiving no anti-platelet therapy. Control thrombosed arteries (without laser energy application) showed no autolysis within 14 days in all dogs and up to 95 days in three dogs followed for this period of time. These data show that rethrombosis of totally occluded, thrombosed arteries is not present up to 2 weeks later after laser recanalization, with or without the aid of anti-platelet therapy.
在16条血栓闭塞的犬股动脉中研究了激光再通术后再血栓形成的潜在问题。通过球囊去内皮化和向人体血液中注射凝血酶产生长度为4.13±1.54 cm的附着性、完全闭塞性血栓；在18.35±22.1小时对血栓进行激光照射。氩激光导管通过近端动脉切开术插入，并以3.83±0.58 W的功率照射411.3±296.87秒。随访期为14天。血管造影显示，所有动脉在激光照射后即刻和14天后均保持通畅。未发生血管穿孔。7只犬在研究前4天及整个研究过程中持续给予阿司匹林和双嘧达莫，但这些犬与未接受抗血小板治疗的犬在血栓长度、激光功率或激光照射持续时间方面并无差异。对照血栓形成动脉（未施加激光能量）在所有犬中14天内均未出现自溶，3只犬在此期间随访长达95天也未出现自溶。这些数据表明，无论有无抗血小板治疗的辅助，完全闭塞的血栓形成动脉在激光再通后2周内均不会出现再血栓形成。
