Crea F, Abela G S, Fenech A, Smith W, Pepine C J, Conti C R
Am J Cardiol. 1986 Jan 1;57(1):171-4. doi: 10.1016/0002-9149(86)90974-4.
In vivo coronary transluminal laser irradiation, using energies known to vaporize atherosclerotic plaques and thrombi, was performed in normal coronary arteries of 5 anesthetized mongrel dogs. A 200-mu core silica optical fiber with a radiopaque tip was advanced through a catheter to either the left anterior descending or circumflex coronary arteries. Coronary artery perforation occurred during manipulation of the fiber in 1 dog. In 4 dogs, argon laser radiation was delivered at 1-second intervals. A total of 45 different sites were irradiated in 8 coronary arteries. In 5 of these arteries 1 W was used and in the 3 other arteries 2 W were used. Coronary angiography showed perforation of 5 of these 8 arteries. Two arteries were perforated using 1 W and 3 using 2 W. Within 30 minutes, 3 dogs with perforation died of cardiac tamponade. In all 4 dogs postmortem examination showed perivascular blood extravasation around all 8 lased coronary arteries. Transluminal lasing of normal dog coronary arteries using delivery systems and energies similar to those known to vaporize atherosclerotic plaques and thrombi resulted in arterial perforation, frequently followed by cardiac tamponade.
在5只麻醉杂种犬的正常冠状动脉中，使用已知能汽化动脉粥样硬化斑块和血栓的能量进行体内冠状动脉腔内激光照射。将一根带有不透射线尖端的200微米芯石英光纤通过导管推进到左前降支或回旋支冠状动脉。在1只犬中，在光纤操作过程中发生了冠状动脉穿孔。在4只犬中，以1秒的间隔进行氩激光照射。在8条冠状动脉中总共照射了45个不同部位。其中5条动脉使用1瓦，另外3条动脉使用2瓦。冠状动脉造影显示这8条动脉中有5条发生穿孔。2条动脉使用1瓦时穿孔，3条使用2瓦时穿孔。30分钟内，3只发生穿孔的犬死于心脏压塞。所有4只犬的尸检显示，所有8条接受激光照射的冠状动脉周围均有血管外渗血。使用与已知能汽化动脉粥样硬化斑块和血栓的系统及能量相似的输送系统和能量，对正常犬冠状动脉进行腔内激光照射会导致动脉穿孔，常继以心脏压塞。
