Mytinger John R, Weber Amanda, Vidaurre Jorge
Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, U.S.A.
Departments of Neurology and.
J Clin Neurophysiol. 2018 Mar;35(2):151-154. doi: 10.1097/WNP.0000000000000449.
To assess for the presence of high amplitude EEG background slow waves in normal young children.
One hundred children with normal development ages 3 to 18 months had normal EEGs for spells and did not have seizures or epilepsy. Three electroencephalographers retrospectively reviewed 5 minutes of stable stage II sleep to measure background slow waves for peak-to-peak amplitudes. A standard 10-20 longitudinal bipolar montage was used. Interrater agreement was assessed by intraclass correlation coefficient.
Interrater agreement between reviewers in the assessment of recurrent slow wave amplitudes was excellent (intraclass correlation coefficient = 0.97). Slow wave amplitudes were the highest in the posterior head regions for all patients. We found recurring slow waves of <200 µV, 200 to 299 µV, 300 to 399 µV, 400 to 499 µV, and >500 µV in 17%, 49%, 30%, 3% and 1%, respectively.
Although hypsarhythmia typically includes high amplitude background slow waves of >200 or >300 µV, we found that 83% and 34% of normal children had recurring posterior background slow waves of >200 or >300 µV, respectively. These data may be useful in the EEG background assessment of young children, for determining the presence or absence of hypsarhythmia, and determining treatment response in children with epileptic spasms.
评估正常幼儿中高振幅脑电图背景慢波的存在情况。
100名年龄在3至18个月发育正常的儿童脑电图检查结果正常，无发作性症状，也没有癫痫发作。三名脑电图技师回顾性分析了5分钟稳定的II期睡眠脑电图，以测量背景慢波的峰峰值。采用标准的10-20纵向双极导联。通过组内相关系数评估评分者间的一致性。
评分者在评估反复出现的慢波振幅方面的一致性非常好（组内相关系数=0.97）。所有患者后头部区域的慢波振幅最高。我们发现，峰峰值<200µV、200至299µV、300至399µV、400至499µV和>500µV的反复出现的慢波分别占17%、49%、30%、3%和1%。
虽然高峰失律通常包括峰峰值>200或>300µV的高振幅背景慢波，但我们发现分别有83%和34%的正常儿童后头部存在反复出现的峰峰值>200或>300µV的背景慢波。这些数据可能有助于幼儿脑电图背景评估、确定是否存在高峰失律以及确定癫痫性痉挛患儿的治疗反应。
