Engineering Research Center of Molecular-imaging and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China.
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
Adv Mater. 2018 Feb;30(8). doi: 10.1002/adma.201704877. Epub 2018 Jan 8.
Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, a reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via a biocompatible metal-polyphenol networks self-assembly process by encapsulating doxorubicin (DOX) and platinum prodrugs in nanoparticles. Both DOX and platinum drugs can activate nicotinamide adenine dinucleotide phosphate oxidases, generating superoxide radicals (O ). The superoxide dismutase-like activity of polyphenols can catalyze H O generation from O . Finally, the highly toxic HO free radicals are generated by a Fenton reaction. The ROS HO can synergize the chemotherapy by a cascade of bioreactions. Positron emission tomography imaging of Zr-labeled as-prepared DOX@Pt prodrug Fe nanoparticles (DPPF NPs) shows prolonged blood circulation and high tumor accumulation. Furthermore, the DPPF NPs can effectively inhibit tumor growth and reduce the side effects of anticancer drugs. This study establishes a novel ROS promoted synergistic nanomedicine platform for cancer therapy.
通过生物相容性的金属-多酚网络自组装过程，将阿霉素（DOX）和铂前药包封在纳米颗粒中，设计了一种活性氧（ROS）增强的联合化疗平台。DOX 和铂药物都可以激活烟酰胺腺嘌呤二核苷酸磷酸氧化酶，产生超氧自由基（O ）。多酚的超氧化物歧化酶样活性可以催化 H O 从 O 生成。最后，通过芬顿反应生成高毒性的 HO 自由基。ROS HO 可以通过级联生物反应协同化疗。Zr 标记的制备的 DOX@Pt 前药 Fe 纳米颗粒（DPPF NPs）的正电子发射断层扫描成像显示延长了血液循环和高肿瘤积累。此外，DPPF NPs 可以有效抑制肿瘤生长并降低抗癌药物的副作用。本研究建立了一种用于癌症治疗的新型 ROS 促进协同纳米医学平台。
