Georgian L, Moraru I
Morphol Embryol (Bucur). 1985 Jul-Sep;31(3):159-61.
The effect of three concentrations, 1, 2 and 4 per cent, of propylene glycol has been investigated on human lymphocytes in vitro. An increased ratio of anaphase cells was observed at 4 per cent propylene glycol in the culture medium, when added for the last 24 h in 72 h blood cultures. No change in chromosome number has concomitantly been observed. A weak stathmokynetic action was induced by the same concentration of propylene glycol if administered for the final two hours of cell cultivation. These effects could be due to a delay in the normal sequence of the sister chromatid separation during mitosis, induced by the highest drug concentration.
已对1%、2%和4%三种浓度的丙二醇在体外对人淋巴细胞的作用进行了研究。在72小时的血液培养中，在最后24小时添加培养基中4%丙二醇时，观察到后期细胞的比例增加。同时未观察到染色体数量的变化。如果在细胞培养的最后两小时给予相同浓度的丙二醇，则会诱导出微弱的有丝分裂抑制作用。这些影响可能是由于最高药物浓度诱导有丝分裂期间姐妹染色单体正常分离顺序延迟所致。
