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N-取代腙的锰催化醇与腙的偶联反应：在一个体系中实现氢的转移和无受体脱氢。

N-Substituted Hydrazones by Manganese-Catalyzed Coupling of Alcohols with Hydrazine: Borrowing Hydrogen and Acceptorless Dehydrogenation in One System.

机构信息

Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel.

Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.

出版信息

Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2179-2182. doi: 10.1002/anie.201712593. Epub 2018 Jan 29.

DOI:10.1002/anie.201712593
PMID:29316100
Abstract

An unprecedented one-step synthesis of N-substituted hydrazones by coupling of alcohols with hydrazine is reported. This partial hydrogen-borrowing reaction is catalyzed by a new manganese pincer complex under mild reaction conditions, thus liberating water and dihydrogen as the only byproducts. Mechanistic insight, based on the observation of intermediates, is provided.

摘要

报道了一种通过醇与肼缩合反应，在温和的反应条件下，在新型锰钳形配合物的催化作用下，以水和氢气为唯一副产物，实现 N-取代腙的前所未有的一步合成方法。基于中间体的观察，提供了对该反应机理的深入了解。

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