多穗柯因和杜瑞醇衍生物对玉米穗螟和茄二十八星瓢虫的拒食作用及定量构效关系分析。

Antifeedant effect of polygodial and drimenol derivatives against Spodoptera frugiperda and Epilachna paenulata and quantitative structure-activity analysis.

机构信息

Escuela de Obstetricia y Puericultura, Facultad de Medicina, Campus de la Salud, Universidad de Valparaíso, Viña del Mar, Chile.

Centro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Viña del Mar, Chile.

出版信息

Pest Manag Sci. 2018 Jul;74(7):1623-1629. doi: 10.1002/ps.4853. Epub 2018 Mar 2.

DOI:10.1002/ps.4853

PMID:29316155

Abstract

BACKGROUND

The antifeedant activity of 18 sesquiterpenoids of the drimane family (polygodial, drimenol and derivatives) was investigated.

RESULTS

Polygodial, drimanic and nordrimanic derivatives were found to exert antifeedant effects against two insect species, Spodoptera frugiperda and Epilachna paenulata, which are pests of agronomic interest, indicating that they have potential as biopesticide agents. Among the 18 compounds tested, the epoxynordrimane compound (11) and isonordrimenone (4) showed the highest activity [50% effective concentration (EC ) = 23.28 and 25.63 nmol cm , respectively, against S. frugiperda, and 50.50 and 59.00 nmol/cm , respectively, against E. paenulata].

CONCLUSION

The results suggest that drimanic compounds have potential as new agents against S. frugiperda and E. paenulata. A quantitative structure-activity relationship (QSAR) analysis of the whole series, supported by electronic studies, suggested that drimanic compounds have structural features necessary for increasing antifeedant activity, namely a C-9 carbonyl group and an epoxide at C-8 and C-9. © 2018 Society of Chemical Industry.

摘要

背景

研究了来自裂烷家族的 18 种倍半萜（聚酮、二烯醇及其衍生物）的拒食活性。

结果

发现聚酮、二烯和诺二烯衍生物对两种农业害虫具有拒食作用，即对鳞翅目昆虫玉米穗螟和茄二十八星瓢虫，这表明它们具有作为生物农药的潜力。在测试的 18 种化合物中，环氧诺二烯化合物（11）和异诺二烯酮（4）表现出最高的活性[对 S. frugiperda 的 50%有效浓度（EC ）分别为 23.28 和 25.63 nmol/cm ，对 E. paenulata 的 50.50 和 59.00 nmol/cm ]。