Liskowsky D R, Potter L T
Neurosci Lett. 1985 Jul 31;58(2):229-33. doi: 10.1016/0304-3940(85)90169-7.
The effects of lesions to the mesocortical dopaminergic system on D2 dopamine receptors and muscarine receptors in the frontal cortex of the rat was examined. Four weeks following 6-hydroxydopamine lesioning of the ventral tegmental area, there was a 26% increase in the number of [3H]spiroperidol sites, and a 13% decrease in the number of [3H]oxotremorine-M sites in the frontal cortex, indicating a development of D2 receptor supersensitivity, as a result of deafferentation, and a loss of acetylcholine sites, as result of terminal degeneration. This demonstrates that in the frontal cortex, as in the striatum and nucleus accumbens, the activity of dopaminergic terminals may be partially modulated by cholinergic inputs.
研究了中脑皮质多巴胺能系统损伤对大鼠额叶皮质中D2多巴胺受体和毒蕈碱受体的影响。在腹侧被盖区进行6-羟基多巴胺损伤四周后，额叶皮质中[3H]螺哌啶醇结合位点数量增加了26%，[3H]氧代震颤素-M结合位点数量减少了13%，这表明去传入导致D2受体超敏反应的发生，以及终末变性导致乙酰胆碱结合位点的丧失。这表明在额叶皮质中，与纹状体和伏隔核一样，多巴胺能终末的活动可能部分受胆碱能输入的调节。
