生物钟与 UPＲ：故事的新转折

Circadian Clocks and UPR: New Twists as the Story Unfolds.

机构信息

Center for Integrative Genomics, University of Lausanne, Génopode, 1015 Lausanne, Switzerland.

出版信息

Dev Cell. 2018 Jan 8;44(1):7-9. doi: 10.1016/j.devcel.2017.12.018.

DOI:10.1016/j.devcel.2017.12.018

Abstract

Circadian clocks help control the unfolded protein response (UPR). In a recent issue of Nature Cell Biology, Bu et al. (2017) show that the interaction is reciprocal, with miRNA-211 providing a signal from the UPR to the clock component BMAL1, affecting circadian timing, global translational control, and cancer cell survival.

摘要

生物钟有助于控制未折叠蛋白反应（UPR）。在最近一期的《自然细胞生物学》杂志上，Bu 等人（2017）表明，这种相互作用是相互的，miRNA-211 从 UPR 向生物钟组件 BMAL1 提供信号，影响生物钟的时间、全局翻译控制和癌细胞的存活。