Proietti Cecilia J, Cenciarini Mauro E, Elizalde Patricia V
Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina.
Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina.
Steroids. 2018 May;133:75-81. doi: 10.1016/j.steroids.2017.12.015. Epub 2018 Jan 6.
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer. As a member of the nuclear receptor family of ligand-dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, progesterone. Liganded-PR transcriptional activation has been thoroughly studied and associated mechanisms have been described while progesterone-mediated repression has remained less explored. The present work summarizes recent advances in the understanding of how PR-mediated repression is accomplished in breast cancer cells and highlights the significance of fully understanding the determinants of context-dependent PR action.
孕激素受体（PR）是女性生殖组织中的主要调节因子，可控制生殖周期和孕期的发育过程、增殖及分化。PR在激素依赖性乳腺癌进展中也发挥作用。作为配体依赖性转录因子核受体家族的成员，PR的主要作用是通过结合其同源甾体激素孕酮来调节靶基因表达网络。配体结合的PR转录激活已得到充分研究，相关机制也已阐明，而孕酮介导的抑制作用仍研究较少。本研究总结了在理解乳腺癌细胞中PR介导的抑制作用如何实现方面的最新进展，并强调了全面理解PR作用的上下文依赖性决定因素的重要性。
