Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina.
Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina.
Steroids. 2019 Dec;152:108503. doi: 10.1016/j.steroids.2019.108503. Epub 2019 Sep 25.
The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation in the mammary gland. In addition, experimental and clinical evidence demonstrate their critical role in controlling mammary gland tumorigenesis and breast cancer development. When bound to its ligand, the main action of PR is as a transcription factor, which regulates the expression of target genes networks. PR also activates signal transduction pathways through a rapid or non-genomic mechanism in breast cancer cells, an event that is fully integrated with its genomic effects. This review summarizes the molecular mechanisms of the ligand-activated PR actions that drive epithelial cell proliferation and the regulation of the stem cell population in the normal breast and in breast cancer.
卵巢甾体激素孕激素及其核受体孕激素受体（PR）在乳腺细胞增殖和分化的调节中发挥着重要作用。此外，实验和临床证据表明它们在控制乳腺肿瘤发生和乳腺癌发展中具有关键作用。当与配体结合时，PR 的主要作用是作为转录因子，调节靶基因网络的表达。PR 还通过乳腺癌细胞中的快速或非基因组机制激活信号转导途径，这一事件与它的基因组效应完全整合。这篇综述总结了配体激活的 PR 作用的分子机制，这些作用驱动着正常乳腺和乳腺癌中上皮细胞的增殖和干细胞群体的调节。
