University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India.
UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles and Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh 160014, India.
Drug Discov Today. 2018 Apr;23(4):763-770. doi: 10.1016/j.drudis.2018.01.021. Epub 2018 Jan 6.
Several randomized clinical trials have divulged that administration of antioxidants during chemotherapy decreases the effectiveness of treatment. Hence, the characteristic feature of this article is extensive assessment of putative benefits and potential risks of natural and synthetic antioxidant supplementation, administered with chemotherapy, based upon the available preclinical and clinical data. After analyzing mixed results, it was concluded that current FDA guidelines should be followed before supplementing antioxidants during cytotoxic treatment. Nevertheless, contradictory experimental animal models opposing human clinical trials discourage the concurrent administration of antioxidants ostensibly owing to the possibility of tumor protection and reduced survival.
几项随机临床试验表明，在化疗期间使用抗氧化剂会降低治疗效果。因此，本文的特点是广泛评估了基于现有临床前和临床数据，在化疗期间使用天然和合成抗氧化剂补充剂的潜在益处和潜在风险。在分析了混合结果后，得出的结论是，在细胞毒性治疗期间补充抗氧化剂之前，应遵循当前的 FDA 指南。然而，与人类临床试验相反的实验动物模型却令人沮丧，这表明抗氧化剂不能同时使用，因为这可能会保护肿瘤并降低存活率。
