Kush Preeti, Singh Ranjit, Kumar Parveen
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University Gangoh, Saharanpur 247341, Uttar Pradesh, India.
Exigo Recycling Pvt Ltd., Karnal 132114, Haryana, India.
Gels. 2025 Jan 18;11(1):76. doi: 10.3390/gels11010076.
Cancer is the second leading cause of death globally and the estimated number of new cancer cases and deaths will be ∼30.2 million and 16.3 million, respectively, by 2040. These numbers cause massive, physical, emotional, and financial burdens to society and the healthcare system that lead to further research for a better and more effective therapeutic strategy to manage cancer. Metal-organic frameworks (MOFs) are promising alternative approaches for efficient drug delivery and cancer theranostics owing to their unique properties and the direct transportation of drugs into cells followed by controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, and limited surface accessibility. Therefore, MOFs were conjugated with polymeric hydrogels, leading to the formation of MOF-based hydrogels with abundant absorption sites, flexibility, and excellent mechanical properties. This review briefly describes the different strategies used for the synthesis and characterization of MOF-based hydrogels. Further, we place special emphasis on the recent advances in MOF-based hydrogels used to manage different cancers. Finally, we conclude the challenges and future perspectives of MOF-based hydrogels. We believe that this review will help researchers to develop more MOF-based hydrogels with augmented anticancer effects, enabling the effective management of cancer even without adverse effects.
癌症是全球第二大死因，预计到2040年，新增癌症病例和死亡人数将分别达到约3020万和1630万。这些数字给社会和医疗系统带来了巨大的身体、情感和经济负担，促使人们进一步研究更好、更有效的癌症治疗策略。金属有机框架（MOF）因其独特的性质以及能将药物直接输送到细胞中并实现控释，成为高效药物递送和癌症诊疗的有前景的替代方法，但它们存在一些局限性，如刚性、分散性差、易碎、聚集可能性以及表面可及性有限等。因此，将MOF与聚合物水凝胶共轭，形成了具有丰富吸收位点、柔韧性和优异机械性能的基于MOF的水凝胶。本文综述简要描述了用于合成和表征基于MOF的水凝胶的不同策略。此外，我们特别强调了用于治疗不同癌症的基于MOF的水凝胶的最新进展。最后，我们总结了基于MOF的水凝胶面临的挑战和未来前景。我们相信，这篇综述将有助于研究人员开发出更多具有增强抗癌效果的基于MOF的水凝胶，从而实现对癌症的有效管理且无不良影响。
