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以双侧卵巢转移为表现的原发性空肠腺癌

Primary Jejunal Adenocarcinoma Presenting as Bilateral Ovarian Metastasis.

作者信息

Ofori Emmanuel, Ramai Daryl, Papafragkakis Charilaos, Changela Kinesh, Krishnaiah Mahesh

机构信息

Department of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, 121 Dekalb Avenue, Brooklyn, NY 11201, USA.

Department of Anatomical Sciences, St George's University School of Medicine, True Blue, Grenada, WI.

出版信息

Gastroenterology Res. 2017 Dec;10(6):366-368. doi: 10.14740/gr879w. Epub 2018 Jan 3.

Abstract

Small intestinal tumors are rare with adenocarcinoma of the small intestine accounting for less than 2% of all gastrointestinal cancers. Primary jejunal adenocarcinoma constitutes a minute portion of small intestine adenocarcinomas. Clinically, this cancer presents at latter stages of its progression, mainly due to vague and non-specific symptoms, and the difficulty encountered in accessing the jejunum on upper endoscopy. Diagnosis of jejunal adenocarcinoma is usually inconclusive with the use of computed tomography (CT) scan, small bowel series, or upper endoscopy. Laparoscopy followed by frozen section biopsy provides a definitive diagnosis. In the past decade, balloon-assisted enteroscopy (BAE) and capsule endoscopy have become popular as useful modalities for diagnosing small bowel diseases. Wide excisional jejunectomy is the only treatment option with an estimated 5-year survival of 40-65%. Physicians are advised to suspect jejunal adenocarcinoma as a differential diagnosis in patients who present with non-specific symptoms of abdominal pain, nausea, vomiting, weight loss, anemia, gastrointestinal bleeding or signs of small bowel obstruction. We present a rare case of a 37-year-old woman with suspected bilateral ovarian masses, which was immunohistochemically confirmed as primary jejunal adenocarcinoma with bilateral ovarian metastasis.

摘要

小肠肿瘤较为罕见,小肠腺癌占所有胃肠道癌症的比例不到2%。原发性空肠腺癌在小肠腺癌中所占比例极小。临床上,这种癌症在进展后期才出现,主要是由于症状模糊且不具特异性,以及上消化道内镜检查时进入空肠存在困难。空肠腺癌的诊断通常通过计算机断层扫描(CT)、小肠造影或上消化道内镜检查都难以确诊。腹腔镜检查并进行冰冻切片活检可提供明确诊断。在过去十年中,气囊辅助小肠镜检查(BAE)和胶囊内镜已成为诊断小肠疾病的常用有效方法。广泛切除空肠是唯一的治疗选择,估计5年生存率为40%-65%。建议医生在出现腹痛、恶心、呕吐、体重减轻、贫血、胃肠道出血或小肠梗阻迹象等非特异性症状的患者中,将空肠腺癌作为鉴别诊断考虑。我们报告一例罕见病例,一名37岁女性疑似双侧卵巢肿块,经免疫组化证实为原发性空肠腺癌伴双侧卵巢转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26bd/5755639/566d321ec5a7/gr-10-366-g001.jpg

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