Liu Jiangwei, Liu Yan, Huang Jianzhao, Huang Lei, Zhao Pengwei
Department of Hepatobiliary Surgery, Guizhou Provincial People's Hospital, Guizhou550002, China.
Open Med (Wars). 2017 Dec 29;12:474-480. doi: 10.1515/med-2017-0066. eCollection 2017.
This study compared the realtime monitoring effects of conventional ultrasound and contrast-enhanced ultrasound (CEUS) on evaluating radio frequency ablation (RFA) in a living swine liver model.
Liver RFA was performed on 10 young swine. Conventional ultrasound and CEUS were performed immediately. After the animals were sacrificed, ablation lesions were removed to histopathologically examine the range of the lesions. Ablation completeness based on three methods were compared using histopathology as the gold standard.
Forty-three ablation lesions were produced in the animals. The horizontal diameter, vertical diameter and ablation lesion area based on conventional ultrasound were all significantly smaller than those based on the gross sample, but no significant differences existed between the results of the CEUS and the gross sample. Histopathology showed that 30 lesions were incompletely ablated and 13 were completely ablated, while CEUS showed that 28 lesions were incompletely ablated and 15 were completely ablated. Compared with histopathology, CEUS had an accuracy of 81.4%, a sensitivity of 83.3%, and a specificity of 76.9%. No significant difference in ablation completeness judgment between CEUS and histopathology was observed.
CEUS provides a real-time radiological foundation for evaluating RFA lesion ranges and completeness in a living swine liver model.
本研究比较了传统超声和超声造影（CEUS）在活体猪肝模型中评估射频消融（RFA）的实时监测效果。
对10只幼猪进行肝脏RFA。立即进行传统超声和CEUS检查。动物处死后，取出消融灶进行组织病理学检查以确定病灶范围。以组织病理学为金标准，比较基于三种方法的消融完整性。
动物共产生43个消融灶。基于传统超声的水平直径、垂直直径和消融灶面积均显著小于大体标本，但CEUS结果与大体标本之间无显著差异。组织病理学显示30个病灶消融不完全，13个病灶完全消融，而CEUS显示28个病灶消融不完全，15个病灶完全消融。与组织病理学相比，CEUS的准确率为81.4%，灵敏度为83.3%，特异度为76.9%。CEUS与组织病理学在消融完整性判断上无显著差异。
CEUS为评估活体猪肝模型中RFA病灶范围和完整性提供了实时影像学依据。
