Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, IL, USA.
Food Funct. 2018 Jan 24;9(1):96-106. doi: 10.1039/c7fo01843f.
Strawberries contain a wide array of nutrients and phytochemicals including polyphenols such as anthocyanins, proanthocyanidins and ellagitannins. These polyphenols are absorbed and metabolized to various phenolic metabolites/conjugates in the body, which may play a role in disease risk reduction. In the present study, we investigated the metabolic fate of strawberry polyphenols after chronic (90 days) supplementation of freeze-dried strawberry (24 g d, equivalent to 2 cups of fresh strawberries) vs. control powder in 19 healthy older adults. Blood samples were collected at two time-points i.e., fasting (t = 0 h) and 2 h after the breakfast meal. On days 45 and 90 breakfast also included a control or strawberry drink consistent with their treatment randomization. A total of 21 polyphenolic metabolites were quantified in plasma consisting of 3 anthocyanins/metabolites, 3 urolithin metabolites and 15 phenolic acid metabolites. Among anthocyanins/metabolite, pelargonidin glucuronide (85.7 ± 9.0 nmol L, t = 2 h, day 90) was present in the highest concentration. Persistent concentrations of anthocyanins/metabolites, urolithins and some phenolic acids were observed in fasting (t = 0 h) plasma samples on day 45 and 90 after strawberry drink consumption suggesting a role of enteric, enterohepatic recycling or upregulation of gut microbial and/or human metabolism of these compounds. Our results suggest that strawberry polyphenols are absorbed and extensively metabolized, and can persist in the circulation.
草莓含有丰富的营养成分和植物化学物质，包括多酚类化合物，如花青素、原花青素和鞣花单宁。这些多酚类化合物在体内被吸收和代谢为各种酚类代谢物/缀合物，可能在降低疾病风险方面发挥作用。在本研究中，我们研究了 19 名健康老年人在 90 天（相当于 2 杯新鲜草莓）的冻干草莓（24 克干重，相当于 2 杯新鲜草莓）或对照粉末慢性补充后，草莓多酚的代谢命运。在两个时间点采集血样，即空腹（t = 0 h）和早餐后 2 h。在第 45 和 90 天，早餐还包括与治疗随机分组一致的对照或草莓饮料。在血浆中定量了 21 种多酚代谢物，包括 3 种花色苷/代谢物、3 种尿石素代谢物和 15 种酚酸代谢物。在花色苷/代谢物中，矢车菊素葡萄糖苷（85.7 ± 9.0 nmol/L，t = 2 h，第 90 天）的浓度最高。在草莓饮料摄入后第 45 天和第 90 天的空腹（t = 0 h）血浆样本中，持续存在花色苷/代谢物、尿石素和一些酚酸的浓度，表明肠内、肠肝循环或肠道微生物和/或人类对这些化合物代谢的上调发挥了作用。我们的结果表明，草莓多酚类化合物被吸收并广泛代谢，并且可以在循环中持续存在。
